Objective To investigate the roles of serum amphiregulin(AREG)and mesothelin(MSLN)levels in the auxiliary diagnosis of breast cancer.Methods A total of 54 female patients with breast cancer(breast cancer group),38 patients with benign breast lesions(benign lesion group)and 35 apparently healthy subjects(healthy control group)were enrolled from the Cancer Hospital of Fudan University from December 2018 to May 2019.Serum AREG and MSLN levels were determined by enzyme-linked immunosorbent assay.The relationship between serum AREG and MSLN levels and clinicopathological characteristics of breast cancer patients was analyzed.The efficacy of AREG and MSLN alone and in combination with carcinoembryonic antigen(CEA)and carbohydrate antigen(CA)15-3 in the auxiliary diagnosis of breast cancer was evaluated by receiver operating characteristic(ROC)curve.Results Compared with healthy control group,serum AREG and MSLN levels in breast cancer group were increased(P<0.05).The areas under curves(AUC)of AREG and MSLN in the diagnosis of breast cancer were 0.582 and 0.637,respectively,while the AUC of serum AREG and MSLN combined with CEA and CA15-3 was 0.757.Serum AREG and MSLN levels in breast cancer group were related with pathological types and lymphatic metastasis(P<0.05).Conclusions Serum AREG,MSLN combined with CEA and CA15-3 can play a role in the auxiliary diagnosis of breast cancer.
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