Objective To analyze the roles of thrombin-antithrombin complex(TAT),plasmin-alpha 2-antiplasmin inhibitor complex(PIC)and thromboelastography(TEG)for assessing coagulation function in tumor patients.Methods A total of 120 tumor patients in Cancer Hospital and Shenzhen Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College from January 2022 to August 2023 were enrolled as case group,and 30 healthy subjects were enrolled as control group.The difference of TAT,PIC and TEG were compared.Caprini score was used to compare the differences of TAT,PIC and TEG for the patients with different thrombus risk,and the differences of TAT,PIC and TEG with different tumor types were compared.The efficacy of TAT,PIC and TEG in coagulation function of tumor patients was analyzed by receiver operating characteristic(ROC)curve.Results In case group,TAT and PIC were higher than those in control group(P<0.05).In thrombus extremely high-risk group,TAT and PIC were higher than those in medium/low-risk group(P<0.05).TAT and PIC in patients with liver cancer,lung cancer,colon cancer and gastric cancer were increased(P>0.05).The sensitivities of TAT,PIC and TEG in evaluating the hypercoagulable state of tumor patients were 85.0%,55.0%and 56.70%,and the specificities were 93.3%,81.7%and 70.0%,respectively.The areas under curves were 0.94,0.72 and 0.63,respectively.Conclusions TAT and PIC can determine abnormal coagulation function in tumor patients earlier than TEG,which can better indicate the hypercoagulabe state of tumor patients,and can be used as laboratory parameters for assessing coagulation function in tumor patients.
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