Objective To study the correlation between T lymphocyte subgroup,liver function indexes and traditional Chinese medicine(TCM)syndrome differentiation in chronic hepatitis B(CHB)patients,and to provide a reference for clinical TCM syndrome differentiation,choice of treatment and observation of therapeutic efficacy.Methods Totally,983 patients with CHB were enrolled,and the types of TCM syndrome differentiation were as follows:solid syndrome(270 cases,including 75 cases of damp-heat obstruction syndrome and 195 cases of blood stasis obstruction syndrome)and deficiency syndrome(713 cases,including 662 cases of liver-depression and spleen-deficiency syndrome,28 cases of liver-kidney yin-deficiency syndrome and 23 cases of spleen-kidney yang-deficiency syndrome).By determining liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total protein(TP),albumin(Alb),total bilirubin(TB),direct bilirubin(DBIL)]and T lymphocyte counts(CD3+,CD4+,CD8+),the correlation between each index and TCM syndrome was evaluated.Results The frequency of CHB was as follows:liver-depression and spleen-deficiency＞blood stasis obstruction＞damp-heat obstruction＞liver-kidney yin-deficiency＞spleen-kidney yang-deficiency.Among the CHB syndromes,the patients with spleen-kidney yang-deficiency syndrome were elder,and the patients with damp-heat obstruction syndrome were young.Liver function indexes and T lymphocyte counts had statistical significance among the different syndromes.CD3+and CD4+cell counts were positively correlated with solid and damp-heat obstruction syndromes(P＜0.05),and CD3+and CD4+T cell counts were negatively correlated with spleen-kidney yang-deficiency syndrome(P＜0.05).Conclusions The liver function indexes and T lymphocyte subgroup are correlated with TCM syndrome differentiation in CHB patients,which can provide a reference for clinical TCM syndrome differentiation,choice of treatment and observation of therapeutic efficacy.
T lymphocyte subgroupLiver functionChronic hepatitis BTraditional Chinese medicine syndrome differentiation
万方数据
维普
