Tuberculosis(TB)is one of the most serious global public health threats at present.Drug-resistant tuberculosis(DR-TB)is the focus and difficulty of TB prevention and treatment.This review focuses on the research progress of laboratory diagnostic techniques for DR-TB in terms of phenotypic drug susceptibility testing,including susceptibility testing for anti-TB agents using solid or liquid media and minimum inhibitory concentration methods.Molecular drug susceptibility testing includes GeneXpert MTB/RIF,line probe assay,gene chip method,fluorescence polymerase chain reaction(PCR)melting curve method,FluoroType MTBDR,Xpert MTB/XDR,nucleic acid mass spectrometry system and whole genome sequencing.The aim of this review is to provide a reference for the early diagnosis of DR-TB.
关键词
耐药结核病/表型药物敏感性检测/分子药物敏感性检测
Key words
Drug-resistant tuberculosis/Phenotypic drug susceptibility test/Molecular drug susceptibility testing
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