儿童侵袭性无乳链球菌血清型和耐药性分析
Serotypes and drug resistance of invasive Streptococcus agalactiae in children
陈寰 1董方 2吕志勇 2甄景慧 2陈梅 2苏建荣1
作者信息
- 1. 首都医科大学附属北京友谊医院临床检验中心,北京 100050
- 2. 国家儿童医学中心 首都医科大学附属北京儿童医院检验中心,北京 100045
- 折叠
摘要
目的 分析儿童侵袭性无乳链球菌(B组链球菌,GBS)血清型和耐药性,为减少GBS感染和临床合理用药提供参考.方法 收集2012年1月—2018年12月首都医科大学附属北京儿童医院分离自139例患儿无菌部位临床样本的GBS,进行血清分型和体外药物敏感性试验.结果 139例患儿以新生儿为主(61.2%),其次为婴儿期患儿(38.8%).共分离出185株侵袭性GBS,其中46.0%(64/139)分离自血液样本,20.9%(29/139)分离自脑脊液样本,33.1%(46/139)同时分离自血液和脑脊液样本.共检出5种血清型,以Ⅲ型检出率最高,占54.6%(76/139),以下依次为Ⅰb型(28.1%,39/139)、Ⅰa型(12.9%,18/139)、Ⅱ型和Ⅴ型(2.2%,3/139).139株GBS对红霉素的耐药率最高(89.9%),其次为克林霉素(74.1%),对左氧氟沙星的耐药率为31.7%.未检测出对青霉素、头孢曲松、头孢吡肟、利奈唑胺、万古霉素不敏感的菌株.不同血清型GBS耐药性有一定差异.结论 GBS引起的儿童侵袭性感染主要为血流感染和脑膜炎,掌握其血清型和耐药特征,对儿童临床感染的预防和治疗具有重要意义.
Abstract
Objective To investigate the serotypes and drug resistance causing invasive Streptococcus agalactiae(Group B Streptococcus,GBS)infection in children,and to provide a reference for clinical reduction of GBS infection and rational drug treatment.Methods GBS was isolated from sterile site specimens in Beijing Friendship Hospital of Capital Medical University from January 2012 to December 2018,and serotyping and in vitro drug susceptibility test were performed.Results Totally,139 cases were neonates(61.2%),followed by infants(38.8%).A total of 185 isolates of invasive GBS were isolated,of which 46.0%(64/139)were isolated from blood specimens,20.9%(29/139)were isolated from cerebrospinal fluid specimens,and 33.1%(46/139)were isolated from both blood and cerebrospinal fluid specimens.A total of 5 serotypes were isolated,of which type Ⅲ had the highest determination rate(54.6%,76/139),followed by type Ⅰb(28.1%,39/139),type Ⅰa(12.9%,18/139),type Ⅱ and type Ⅴ(2.2%,3/139,respectively).The drug resistance rate of 139 isolates of GBS to erythromycin was the highest(89.9%),followed by clindamycin(74.1%)and levofloxacin(31.7%).No isolates insensitive to penicillin,ceftriaxone,cefepime,linezolid and vancomycin were determined.There were some differences in drug resistance among different serotypes of GBS.Conclusions Invasive GBS infection in children can cause bloodstream infection and meningitis,and serotyping and drug susceptibility test are important for the prevention and treatment of pediatric clinical infections.
关键词
无乳链球菌/儿童/侵袭性感染/血清型/耐药性Key words
Streptococcus agalactiae/Children/Invasive infection/Serotype/Drug resistance引用本文复制引用
出版年
2024
NETL
NSTL
万方数据