卵巢癌微环境调控调节性T细胞的研究进展
Research progress on the regulation of regulatory T cells in ovarian cancer tumor microenvironment
张珩 1郑慧 1卢仁泉1
作者信息
- 1. 复旦大学附属肿瘤医院检验科 复旦大学上海医学院肿瘤学系,上海 200032
- 折叠
摘要
卵巢癌是导致女性癌症死亡的主要原因之一.虽然免疫治疗方法已用于卵巢癌的临床治疗,但有效率较低.肿瘤微环境中存在免疫抑制因素,提示免疫系统失衡与卵巢癌进展密切相关.调节性T细胞(Treg)是一群发挥抑制效应的T细胞亚群,作为维持自身免疫耐受的重要组成部分,是肿瘤免疫、自身免疫和维持机体免疫稳态的关键.Treg在卵巢癌微环境中发挥重要作用,参与介导免疫耐受,影响卵巢癌的进展和预后.文章对卵巢癌微环境调控Treg的研究进展进行总结.
Abstract
Ovarian cancer is one of the main causes of female cancer death.Although immunotherapy has been used clinically for ovarian cancer,the effective rate of immunotherapy in ovarian cancer is low.There are immunosuppressive factors in tumor microenvironment,the progression of ovarian cancer may be associated with imbalance of immune system.As an important suppressive T cell subset,regulatory T cells(Treg)play roles in tumor immunity,autoimmunity and maintaining immune tolerance.Treg plays an important role in tumor microenvironment of ovarian cancer,participating in anti-tumor immune tolerance and associating with the progression and prognosis of ovarian cancer.This review mainly focuses on the research progress of tumor microenvironment on Treg in ovarian cancer.
关键词
调节性T细胞/卵巢癌/肿瘤微环境/免疫耐受Key words
Regulatory T cell/Ovarian cancer/Tumor microenvironment/Immune tolerance引用本文复制引用
基金项目
上海市"科技创新行动计划"启明星项目(扬帆专项)(22YF1407900)
出版年
2024
NETL
NSTL
万方数据