AECOPD患者UA/Cr比值、NLR与低氧血症的关系
Relationship between uric acid/creatinine ratio and neutrophil/lymphocyte ratio and hypoxemia in patients with acute exacerbation of chronic obstructive pulmonary disease
周瑞玲 1张新宇 1任晓玲 2张雯 1樊长征 1张琼1
作者信息
- 1. 中国中医科学院西苑医院,北京 100091
- 2. 中国中医科学院广安门医院,北京 100053
- 折叠
摘要
目的 探讨血尿酸(UA)/肌酐(Cr)比值和中性粒细胞/淋巴细胞比值(NLR)在急性加重期慢性阻塞性肺疾病(AECOPD)患者合并低氧血症中的临床意义.方法 回顾性分析2019年1月—2021年12月中国中医科学院西苑医院126例AECOPD患者的临床资料.根据动脉血氧分压(PaO2)水平将126例患者分为低氧血症组(86例,PaO2＜83 mmHg)和非低氧血症组(40例,PaO2≥83 mmHg).比较2组患者中医证型、相关临床资料和相关实验室指标的差异.采用Spearman/Pearson相关分析评估UA/Cr比值、NLR与AECOPD合并低氧血症患者第1秒用力呼气容积(FEV1)/用力肺活量(FVC)、第1秒用力呼气容积占预计值的百分比(FEV1pred％)、慢性阻塞性肺疾病自我评估测试(CAT)评分、改良版英国医学研究委员会(mMRC)呼吸困难分级的相关性.采用受试者工作特征(ROC)曲线分析UA/Cr比值、NLR单项和联合预测AECOPD患者合并低氧血症的效能.结果 低氧血症组UA/Cr比值和NLR均高于非低氧血症组(P＜0.001).2组各中医证型患者所占比例差异无统计学意义(P＞0.05).UA/Cr比值、NLR与CAT评分、mMRC呼吸困难分级呈正相关(P＜0.05),与FEV1/FVC、FEV1pred％呈负相关(P＜0.05).UA/Cr比值、NLR单项和联合预测AECOPD患者合并低氧血症的曲线下面积分别为0.792、0.768、0.876.结论 UA/Cr比值和NLR可用于预测AECOPD患者合并低氧血症,2项指标联合使用预测效能更高.
Abstract
Objective To investigate the clinical roles of uric acid(UA)/creatinine(Cr)ratio and neutrophil/lymphocyte ratio(NLR)in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)combined with hypoxemia.Methods The clinical data of 126 patients with AECOPD in Xiyuan Hospital of China Academy of Chinese Medical Sciences from January 2019 to December 2021 were analyzed retrospectively,and the 126 patients were classified into hypoxemia group[86 cases,partial pressure of oxygen(PaO2)＜83 mmHg]and non-hypoxemia group(40 cases,PaO2≥ 83 mmHg)according to the level of PaO2.The differences of traditional Chinese medicine syndromes,clinical data and related laboratory indexes were compared between the 2 groups.The correlation of UA/Cr ratio,NLR and forced expiratory volume in one second(FEV1)/forced vital capacity(FVC),percentage of forced expiratory volume in one second in predicted value(FEV1pred％),chronic obstructive pulmonary disease assessment test(CAT)score and modified Medical Research Council(mMRC)dyspnea grade of patients with AECOPD combined with hypoxemia was analyzed by Spearman/Pearson correlation analysis.Receiver operating characteristic(ROC)curves were used to analyze the efficacy of UA/Cr ratio and NLR single and combined determinations in predicting hypoxemia in AECOPD patients.Results The UA/Cr ratio and NLR in hypoxemia group were higher than those in non-hypoxemia group(P＜0.001).There was no statistical significance in the proportion of patients with traditional Chinese medicine syndromes between the 2 groups(P＞0.05).UA/Cr ratio and NLR were positively correlated with CAT score and mMRC dyspnea grade(P＜0.05)and were negatively correlated with FEV1/FVC and FEV1pred％(P＜0.05).ROC curve analysis showed that the areas under curves of UA/Cr ratio and NLR single and combined determinations of AECOPD patients with hypoxemia were 0.792,0.768 and 0.876,respectively.Conclusions UA/Cr ratio and NLR can be used to predict patients with AECOPD combined with hypoxemia,and the combined determination is effective.
关键词
慢性阻塞性肺疾病/低氧血症/尿酸/肌酐比值/中性粒细胞/淋巴细胞比值/中医证型Key words
Chronic obstructive pulmonary disease/Hypoxemia/Uric acid/creatinine ratio/Neutrophil/lymphocyte ratio/Traditional Chinese medicine syndrome引用本文复制引用
基金项目
中国中医科学院科技创新项目(CI2021A01106)
中国中医科学院科技创新项目(CI2021A01104)
出版年
2024
NETL
NSTL
万方数据