Objective To investigate the clinical value of inflammatory derived indicators[derived neutrophil-to-lymphocyte ratio(dNLR)and systemic inflammatory response index(SIRI)]and cystatin C(Cys C)in the prediction of preeclampsia.Methods From January 2019 to November 2022,194 patients with preeclampsia in the International Peace Maternity and Child Health Hospital affiliated to Shanghai Jiao Tong University School of Medicine were enrolled as observation group.A total of 152 healthy pregnant females were enrolled as control group.The relationship between dNLR,SIRI,Cys C and preeclampsia was analyzed.Results The level of Cys C in observation group was higher than that in control group(P＜0.01).The white blood cell count,neutrophil count,monocyte count,dNLR and SIRI in observation group were higher than those in control group(P＜0.01).There was no statistical significance in lymphocyte count,platelet count and mean platelet volume between observation group and control group(P＞0.05).Cys C and dNLR were positively correlated with systolic blood pressure and diastolic blood pressure,respectively(P＜0.01).SIRI was positively correlated with diastolic blood pressure(P＜0.05).The combined determination of Cys C,dNLR and SIRI predicted preeclampsia with an area under curve of 0.852[95％confidence interval(CI)0.812-0.892,P＜0.01],and the sensitivity and specificity were 61.8％and 92.7％,respectively.Cys C≥0.905 mg·L-1,dNLR≥2.950,SIRI≥2.315 were independent risk factors for preeclampsia(P＜0.05).The observation group was sub-classified according to the optimal cut-off values of Cys C,dNLR and SIRI.There was no statistical significance in pregnancy outcome between high level groups and low level groups(P＞0.05).Conclusions Cys C,dNLR and SIRI are independent risk factors for preeclampsia,and they have good sensitivity and specificity,which have certain value for prediction and evaluation of preeclampsia.
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