EB病毒感染急性淋巴细胞白血病患儿临床特征分析
Clinical characteristics of acute lymphoblastic leukemia children infected with Epstein-Barr virus
闫江泓 1王乐 1马琳 2杨硕 1郭巍巍 1赵梦川 3刘泽昊 1翟小颖4
作者信息
- 1. 河北省儿童医院儿科研究所,河北石家庄 050000
- 2. 河北省儿童医院病理科,河北石家庄 050000
- 3. 河北省儿童医院检验科,河北石家庄 050000
- 4. 河北省儿童医院血液肿瘤科,河北石家庄 050000
- 折叠
摘要
目的 了解EB病毒感染急性淋巴细胞白血病(ALL)患儿的临床特征,为临床干预提供参考.方法 选取2020年1月—2022年8月河北省儿童医院90例≤17岁ALL住院患儿,根据是否感染EB病毒分为感染组(78例)和未感染组(12例).收集所有患儿临床资料,采用酶联免疫吸附试验检测患儿血清EB病毒抗体谱[抗EB病毒衣壳抗体IgM(EBV-CAIgM)、抗EB病毒早期抗体IgG(EBV-EAIgG)、抗EB病毒衣壳抗体IgG(EBV-CAIgG)、抗EB病毒核抗体IgG(EBV-NA1IgG)].比较2组患儿临床特征和各项指标差异.结果 感染组和未感染组性别、年龄差异均无统计学意义(P＞0.05).急性T淋巴细胞白血病(T-ALL)患儿中EB病毒感染占70.59％(12/17),急性B淋巴细胞白血病(B-ALL)患儿中,EB病毒感染占90.41％(66/73),不同免疫分型患儿EB病毒感染所占比例差异无统计学意义(P＞0.05).B-ALL患儿和T-ALL患儿既往感染所占比例均较高(＞45％).结论 ALL患儿EB病毒既往感染比例较高,临床应加强对ALL患儿EB病毒的筛查和监测.
Abstract
Objective To investigate the clinical characteristics of children with acute lymphoblastic leukemia(ALL)infected by Epstein-Barr(EB)virus,and to provide a reference for clinical intervention.Method A total of 90 ALL children aged≤17 years hospitalized in Hebei Children's Hospital from January 2020 to August 2022 were enrolled and classified into infected group(78 cases)and uninfected group(12 cases)according to whether they were infected with EB virus.The clinical data of 2 groups of children were collected.Serum EB virus antibody profile[anti-EB virus capsid antibody IgM(EBV-CAIgM),anti-EB virus early antibody IgG(EBV-EAIgG),anti-EB virus capsid antibody IgG(EBV-CAIgG),anti-EB virus nuclear antibody IgG(EBV-NA1IgG)]was determined by enzyme-linked immunosorbent assay.The clinical characteristics and various indexes of the 2 groups were compared.Results There was no statistical significance in gender and age between infected and uninfected groups(P＞0.05).Among children with T-acute lymphoblastic leukemia(T-ALL),70.59％(12/17)cases were infected with EB virus,while among children with B-acute lymphoblastic leukemia(B-ALL),90.41％(66/73)cases were infected with EB virus.The difference in the proportion of EB virus infection between children with different immunophenotypes was not statistically significant(P＞0.05).The proportions of previous infections among children with B-ALL and T-ALL were high(＞45％).Conclusions The proportion of EB virus infection in children with ALL is high.Clinical screening and monitoring of EB virus infection in ALL patients should be strengthened.
关键词
EB病毒/急性淋巴细胞白血病/儿童Key words
Epstein-Barr virus/Acute lymphoblastic leukemia/Children引用本文复制引用
基金项目
2021年河北省医学科学研究计划(20210749)
出版年
2024
NETL
NSTL
万方数据