Objective To investigate the clinical characteristics of children with acute lymphoblastic leukemia(ALL)infected by Epstein-Barr(EB)virus,and to provide a reference for clinical intervention.Method A total of 90 ALL children aged≤17 years hospitalized in Hebei Children's Hospital from January 2020 to August 2022 were enrolled and classified into infected group(78 cases)and uninfected group(12 cases)according to whether they were infected with EB virus.The clinical data of 2 groups of children were collected.Serum EB virus antibody profile[anti-EB virus capsid antibody IgM(EBV-CAIgM),anti-EB virus early antibody IgG(EBV-EAIgG),anti-EB virus capsid antibody IgG(EBV-CAIgG),anti-EB virus nuclear antibody IgG(EBV-NA1IgG)]was determined by enzyme-linked immunosorbent assay.The clinical characteristics and various indexes of the 2 groups were compared.Results There was no statistical significance in gender and age between infected and uninfected groups(P＞0.05).Among children with T-acute lymphoblastic leukemia(T-ALL),70.59％(12/17)cases were infected with EB virus,while among children with B-acute lymphoblastic leukemia(B-ALL),90.41％(66/73)cases were infected with EB virus.The difference in the proportion of EB virus infection between children with different immunophenotypes was not statistically significant(P＞0.05).The proportions of previous infections among children with B-ALL and T-ALL were high(＞45％).Conclusions The proportion of EB virus infection in children with ALL is high.Clinical screening and monitoring of EB virus infection in ALL patients should be strengthened.
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