口腔种植体周围炎患者血清干扰素调节因子4、可溶性致癌抑制因子2检测的临床意义
Determinations of serum interferon regulatory factor 4 and soluble suppression of tumorigenicity 2 in patients with oral periimplantitis
吕敏敏 1黄莹 1于兰 1曹丽婷 2曾翠敏3
作者信息
- 1. 沧州市人民医院口腔牙周科,河北 沧州 061000
- 2. 沧州市人民医院儿童牙科,河北 沧州 061000
- 3. 沧州市人民医院口腔修复科,河北 沧州 061000
- 折叠
摘要
目的 探讨口腔种植体周围炎患者血清干扰素调节因子4(IRF4)、可溶性致癌抑制因子2(sST2)检测的临床意义.方法 选取2021年1月—2022年12月沧州市人民医院口腔种植体周围炎患者30例(口腔种植体周围炎组)、同一类型种植体的健康口腔种植体者30例(健康口腔种植体组)和体检健康者30名(正常对照组).检测所有研究对象血清IRF4、sST2水平.采用Pearson相关分析评估血清IRF4、sST2水平与年龄、探诊深度(PD)、龈沟液量、出血指数(SBI)的相关性.采用受试者工作特征(ROC)曲线评估血清IRF4、sST2诊断口腔种植体周围炎的效能.结果 口腔种植体周围炎组PD、龈沟液量、SBI均显著高于健康口腔种植体组和正常对照组(P<0.05).正常对照组、健康口腔种植体组、口腔种植体周围炎组血清IRF4、sST2水平依次升高(P<0.001).口腔种植体周围炎患者男性、女性之间血清IRF4、sST2水平差异均无统计学意义(P>0.05).≥60岁的口腔种植体周围炎患者血清IRF4、sST2水平高于<60岁的患者(P<0.001).血清IRF4、sST2与年龄、PD、龈沟液量、SBI均呈正相关(P<0.05).血清IRF4、sST2单项检测和联合检测诊断口腔种植体周围炎的曲线下面积(AUC)分别为0.919、0.890、0.978.结论 口腔种植体周围炎患者血清IRF4、sST2水平显著升高,与牙周指标密切相关,或可作为口腔种植体周围炎的诊断指标.
Abstract
Objective To investigate the roles of serum interferon regulatory factor 4(IRF4)and soluble suppression of tumorigenicity 2(sST2)in patients with oral periimplantitis.Methods Totally,30 patients with oral periimplantitis treated in Cangzhou People's Hospital from January 2021 to December 2022(oral periimplantitis group)were enrolled,and another 30 healthy oral implant subjects(healthy oral implant group)and 30 healthy subjects(healthy control group)were enrolled.Serum levels of IRF4 and sST2 were compared among all the groups.The correlations of serum IRF4 and sST2 levels with age,periodontal depth(PD),gingival sulcus fluid volume and sulcus bleeding index(SBI)were analyzed by Pearson correlation analysis.Receiver operating characteristic(ROC)curve was used to analyze the predictive values of serum IRF4 and sST2 levels in oral periimplantitis.Results PD,gingival sulcus fluid volume and SBI in oral periimplantitis group were higher than those in healthy oral implant group and healthy control group(P<0.05).Serum IRF4 and sST2 levels in healthy control group,healthy oral implant group and oral periimplantitis group were increased successively(P<0.001).There was no statistical significance in serum IRF4 and sST2 levels between male and female patients with oral periimplantitis(P>0.05).Serum IRF4 and sST2 levels in patients≥60 years old were higher than those in patients<60 years old(P<0.001).Serum IRF4 and sST2 were positively correlated with age,PD,gingival sulcus fluid volume and SBI(P<0.05).The areas under curves(AUC)of serum IRF4 and sST2 single and combined determinations were 0.919,0.890 and 0.978,respectively.Conclusions Serum IRF4 and sST2 levels are increased in patients with oral periimplantitis,which are related to periodontal indexes,and they may be used in the diagnosis of oral periimplantitis.
关键词
干扰素调节因子4/可溶性致癌抑制因子2/口腔种植体周围炎Key words
Interferon regulatory factor 4/Soluble suppression of tumorigenicity 2/Oral periimplantitis引用本文复制引用
基金项目
沧州市重点研发计划指导项目(213106009)
出版年
2024
NETL
NSTL
万方数据