Objective To investigate the role of serum chemokine C-X-C motif ligand 1(CXCL1)and soluble CD40 ligand(sCD40L)in the prognosis of patients with subarachnoid hemorrhage.Methods Totally,218 patients with subarachnoid hemorrhage were enrolled from the Fifth People's Hospital of Qinghai Province from January 2020 to January 2023,which were classified into survival group(153 cases)and death group(65 cases)according to the survival after 90 d of follow-up.The clinical data of all the patients were collected,and serum CXCL1 and sCD40L levels were determined.Logistic regression analysis(stepwise forward method)was used to evaluate the risk factors of death in patients with subarachnoid hemorrhage.The efficacy of serum CXCL1 and sCD40L in determining the death of patients with subarachnoid hemorrhage was analyzed by receiver operating characteristic(ROC)curve.Results There was statistical significance in the time from admission to operation≥72 h,systolic blood pressure,diastolic blood pressure,Glasgow coma scale(GCS)score,Hunt-Hess grade and modified Fisher score between survival group and death group(P<0.05),while there was no statistical significance in the other items between the 2 groups(P>0.05).Serum CXCL1 and sCD40L levels in death group were higher than those in survival group(P<0.001).The time from admission to operation≥72 h,GCS score,Hunt-Hess grade,modified Fisher score,serum CXCL1 and sCD40L were all risk factors for death in patients with subarachnoid hemorrhage(P<0.05).The areas under curves(AUC)for death in patients with subarachnoid hemorrhage were 0.845,0.880 and 0.948 by single and combined determinations of serum CXCL1 and sCD40L levels.Conclusions Serum CXCL1 and sCD40L levels are related to the prognosis of patients with subarachnoid hemorrhage,and they may be used as biomarkers for prognosis evaluation of patients with subarachnoid hemorrhage.
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