维生素D和血糖在子痫前期患者妊娠结局中的协同作用
Synergistic role of vitamin D and blood glucose in pregnancy outcomes in patients with preeclampsia
张静1
作者信息
- 1. 巴音郭楞蒙古自治州人民医院,新疆 库尔勒 841000
- 折叠
摘要
目的 探讨维生素 D(VD)缺乏和高血糖对子痫前期(PE)患者妊娠结局的协同作用.方法 选取2020年1月—2022年3月巴州人民医院PE患者173例.按妊娠结局,将其分为妊娠结局良好组(118例)和妊娠结局不良组(55例).比较2个组一般临床资料和25-羟基维生素D[25(OH)D]、血糖等生化指标结果的差异.采用多因素Logistic回归分析评价PE患者不良妊娠结局的独立危险因素,并通过相加交互模型分析25(OH)D、血糖对不良妊娠结局的交互作用.利用Logistic回归分析评价PE患者25(OH)D和血糖与不良妊娠结局发生风险的关系.结果 VD缺乏、高血糖均为PE患者发生不良妊娠结局的独立危险因素,且两者对PE患者不良妊娠结局的发生具有交互作用.随着25(OH)D水平的升高,不良妊娠结局发生概率逐渐下降.随着患者血糖水平的升高,不良妊娠结局发生概率逐渐升高.25(OH)D与不良妊娠结局发生概率呈显著负相关,尤其当25(OH)D<30 ng·mL-1时,随着其水平升高,不良妊娠结局发生概率显著下降;血糖与不良妊娠结局发生概率呈显著正相关,尤其当血糖<7.5 mmol·L-1时,随着其水平降低,不良妊娠结局发生概率显著下降.25(OH)D、血糖两者协同交互作用对PE患者不良妊娠结局的预测价值大于两者单独对PE患者不良妊娠结局的预测价值.结论 VD缺乏和高血糖是PE患者发生不良妊娠结局的独立危险因素,且互相影响.
Abstract
Objective To investigate the synergistic role of vitamin D(VD)deficiency and high blood glucose in pregnancy outcomes in patients with preeclampsia(PE).Methods Totally,173 PE patients in Bayingol Mongolian Autonomous Prefecture People's Hospital from January 2020 to March 2022 were enrolled.According to the pregnancy outcomes,they were classified into good pregnancy outcome group(118 cases)and poor pregnancy outcome group(55 cases).The differences of general clinical data,25-hydroxyvitamin D[25(OH)D],blood glucose and other biochemical indexes were compared between the 2 groups.Multivariate Logistic regression analysis was used to evaluate the independent risk factors for adverse pregnancy outcomes in PE patients,and the interaction of 25(OH)D and blood glucose on adverse pregnancy outcomes was analyzed by additive interaction model.Logistic regression model was used to analyze the relationship between 25(OH)D,blood glucose and the risk of adverse pregnancy outcomes in PE patients.Results VD deficiency and high blood glucose were independent risk factors for adverse pregnancy outcomes in PE patients,and they had interactive effects on the occurrence of adverse pregnancy outcomes in PE patients.With the increase of 25(OH)D level,the probability of adverse pregnancy outcomes decreased gradually.With the increase of blood glucose level,the probability of adverse pregnancy outcomes increased gradually.There was a negative correlation between 25(OH)D and adverse pregnancy outcomes,especially when 25(OH)D<30 ng·mL-1,and the probability of adverse pregnancy outcomes decreased with the increase of 25(OH)D level.There was a positive correlation between blood glucose and adverse pregnancy outcomes,especially when blood glucose<7.5 mmol·L-1,the probability of adverse pregnancy outcomes decreased with the decrease of blood glucose level.The synergistic interaction value of 25(OH)D and blood glucose in predicting adverse pregnancy outcomes in PE patients was greater than that of the 2 alone.Conclusions VD deficiency and high blood glucose are independent risk factors for adverse pregnancy outcomes in PE patients and influence each other.
关键词
子痫前期/血糖/25-羟基维生素D/妊娠结局/协同作用Key words
Preeclampsia/Blood glucose/25-Hydroxyvitamin D/Pregnancy outcome/Synergy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据