摘要
目的 探讨缺血性脑血管病(ICD)患者血清β淀粉样蛋白(Aβ)和壳多糖酶3样蛋白1(CHI3L1)水平与颈动脉病变的关系.方法 选取2019年1月—2023年5月沧州市中心医院ICD患者298例(ICD组)、健康体检者300名(对照组).根据颈动脉内膜中层厚度(ITM)、斑块积分和颈动脉狭窄程度分别分组.收集所有研究对象一般资料,并检测血清Aβ、CHI3L1、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平.采用偏相关分析评估血清Aβ、CHI3L1水平与颈动脉病变的相关性.结果 ICD组血清TG、TC、LDL-C、Aβ和CHI3L1水平均高于对照组(P<0.01),其他指标2个组之间差异均无统计学意义(P>0.05).内膜正常组、内膜增厚组、斑块形成组血清Aβ和CHI3L1水平依次升高(P<0.001).轻度硬化组、中度硬化组和重度硬化组血清Aβ和CHI3L1水平依次升高(P<0.001).轻度狭窄组、中度狭窄组和重度狭窄组血清Aβ、CHI3L1水平依次升高(P<0.001).血清Aβ和CHI3L1水平与ITM、斑块积分和颈动脉狭窄程度均呈正相关(P<0.001).结论 ICD患者血清Aβ和CHI3L1水平升高,且与颈动脉病变密切相关,或可作为反映ICD患者颈动脉病变程度的指标.
Abstract
Objective To investigate the relationship between serum amyloid beta(Aβ)and chitinase 3-like protein 1(CHI3L1)levels and carotid artery lesions in patients with ischemic cerebrovascular disease(ICD).Methods Totally,298 ICD patients(ICD group)and 300 healthy subjects(healthy control group)were enrolled from Cangzhou Central Hospital from January 2019 to May 2023.The subjects were classified according to carotid intima-media thickness(ITM),plaque score and carotid artery stenosis degree.The general data of all the subjects were collected,and serum levels of Aβ,CHI3L1,glycated hemoglobin A1c(HbA1c),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were determined.Partial correlation analysis was used to evaluate the correlation between serum levels of Aβ and CHI3L1 and carotid artery lesions.Results The levels of serum TG,TC,LDL-C,Aβ and CHI3L1 in ICD group were higher than those in healthy control group(P<0.01),but there was no statistical significance in the other indexes between the 2 groups(P>0.05).Serum levels of Aβ and CHI3L1 in normal tunica intima group,tunica intima thickening group and plaque formation group were increased successively(P<0.001).Serum levels of Aβ and CHI3L1 in mild sclerosis group,moderate sclerosis group and severe sclerosis group were increased successively(P<0.001).Serum levels of Aβ and CHI3L1 in mild stenosis group,moderate stenosis group and severe stenosis group were increased successively(P<0.001).Serum levels of Aβ and CHI3L1 were positively correlated with ITM,plaque score and carotid artery stenosis(P<0.001).Conclusions Serum levels of Aβ and CHI3L1 in ICD patients are increased,which are related to carotid artery lesions,or as indexes to reflect the degree of carotid artery lesions in ICD patients.
基金项目
河北省医学科学研究课题计划项目(20211278)
NETL
NSTL
万方数据