Cryptococcus neoformans is a globally distributed opportunistic fungal pathogen,which causes cryptococcal meningitis,a factor in the mortality of acquired immune deficiency syndrome patients.At present,the kinds of antifungal drugs are limited,which causes in drug resistance and tolerance to Cryptococcus neoformans.In some cases,even if the in vitro drug susceptibility test suggests sensitivity,the treatment with the drug is still prolonged or relapses.This may be associated with drug tolerance.The discovery of drug tolerance responds to more complex mechanisms of antifungal drug resistance.Understanding the drug resistance and tolerance to Cryptococcus neoformans as well as the mechanisms is critical,which can provide ideas for clinical treatment regimen design and the development of new antifungal drugs.
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