Objective To investigate the predictive roles of serum macrophage inflammatory protein-1 alpha(MIP-1α)and human beta defensin 3(hBD3)in postoperative endophthalmitis of cataract patients.Methods A total of 162 patients who underwent cataract surgery in Mianyang Wanjiang Ophthalmology Hospital from March 2020 to March 2022 were enrolled.According to whether endophthalmitis occurred after operation,162 patients were classified into endophthalmitis group(18 cases)and non-endophthalmitis group(144 cases).In addition,98 patients with non-cataract eye diseases in Mianyang Wanjiang Ophthalmology Hospital were enrolled as control group.The correlation between serum MIP-1α and hBD3 was evaluated by Pearson correlation analysis.Multi-variate Logistic regression analysis was used to evaluate the risk factors for postoperative endophthalmitis in cataract patients.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of serum MIP-1α and hBD3 levels on postoperative endophthalmitis in cataract patients.Results The levels of preoperative MIP-1α in endophthalmitis group and non-endophthalmitis group were higher than those in control group,and preoperative hBD3 levels were lower(P<0.05).Serum preoperative MIP-1α level in endophthalmitis group was higher than that in non-endophthalmitis group,and serum preoperative hBD3 level was lower than that in non-endophthalmitis group(P<0.05).Compared with the preoperative results,serum MIP-1α level was decreased,and hBD3 level was increased in cataract patients at 1,3 and 7 d after operation(P<0.05).Compared with non-endophthalmitis group,serum MIP-1α level in endophthalmitis group was increased before and at 1,3 and 7 d after operation,while serum hBD3 level was decreased(P<0.05).Serum MIP-1α was negatively correlated with hBD3 in endophthalmitis group(r=-0.859,P<0.05).MIP-1α was a risk factor for postoperative endophthalmitis in cataract patients(P<0.05),and hBD3 was a protective factor(P<0.05).The areas under curves(AUC)of preoperative MIP-1α and hBD3 to predict postoperative endophthalmitis in cataract patients were 0.769 and 0.819,respectively,while the AUC of combined determination of MIP-1α and hBD3 to predict postoperative endophthalmitis in cataract patients was 0.954,which was higher than those of serum MIP-1α and hBD3 single determinations(P<0.05).Conclusions Serum MIP-1α and hBD3 levels are related to the occurrence of postoperative endophthalmitis in cataract patients.The combined determination of MIP-1α and hBD3 is more effective in predicting postoperative endophthalmitis than MIP-1α and hBD3 single determinations.
万方数据
维普
