Hepatitis B virus(HBV)infection is a public global health problem that leads to a variety of diseases including cirrhosis and hepatocellular carcinoma(HCC).HBV S region genome encodes hepatitis B virus large surface protein(LHB),hepatitis B virus middle surface protein(MHB)and hepatitis B virus small surface protein(SHB),and mutations in its genome that form variant S proteins accumulate in large quantities in the endoplasmic reticulum of hepatocytes,which in turn produce endoplasmic reticulum stress(ERS).ERS and unfolded protein response(UPR)activation are involved in the onset,development and response to therapy of HCC and play roles in the pathogenesis of HCC.This review focuses on the progress of research related to ERS causing HCC by the accumulation of variant S proteins in the endoplasmic reticulum due to HBV PrsS/S region gene mutation.
Hepatitis B virusS region gene mutationEndoplasmic reticulum stressHepatocellular carcinoma
万方数据
维普
