摘要
目的:探讨40岁以下年轻女性乳腺癌患者不同分子亚型的超声声像图特征.方法:回顾并分析2019年1月—2023年5月于南京中医药大学附属医院行乳腺超声检查并行乳腺癌切除术,且经手术后病理学检查证实为乳腺癌的年轻女性患者60例.按免疫组织化学检查结果分为Luminal A型、Luminal B型、三阴性型及人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)过表达型,分析不同亚型在肿块最大径、方位、纵横比、形态、边界、边缘毛刺征、内部回声、钙化灶、后方回声、血流分级、弹性评分方面的超声特点.结果:在60例乳腺癌患者中,Luminal A型较为常见(40.0%),HER2过表达型最少见(15.0%).在不同分子亚型中,肿物的边缘毛刺征、钙化灶、后方回声差异有统计学意义(P＜0.05),其中Luminal A型与Luminal B型多以边缘毛刺征(79.2%、55.3%)为主要表现,三阴性型多以后方回声增强或不变(91.7%)为主要表现,HER2过表达型多以钙化灶(88.9%)为主要表现.而在肿块最大径、方位、纵横比值、形态、边界、内部回声、血流分级、弹性评分中差异无统计学意义(P＞0.05).结论:年轻女性乳腺癌患者的超声声像图特征与其分子亚型存在一定相关性,可为术前预测乳腺癌分子亚型提供有价值的参考.
Abstract
Objective:To investigate ultrasound sonographic characteristics of different molecular subtypes of breast cancer in young women under the age of 40 years.Methods:A retrospective analysis of 60 young patients diagnosed in The Affiliated Hospital of Nanjing University of Chinese Medicine from January 2019 to May 2023 was conducted,who had received breast ultrasound examination and breast cancer resection,then they were pathologically confirmed as breast cancer after surgery.The cases were divided into type Luminal A,type Luminal B,triple-negative type and human epidermal growth factor receptor 2(HER2)overexpression type according to immunohistochemistry.The ultrasound characteristics of different subtypes in the maximum diameter,the orientation,the aspect ratio,the shape,the boundary,marginal spiculate,internal echo,calcification,posterior echo,the blood flow grade,and the elastic score of the mass were analyzed.Results:In 60 breast cancer cases,Luminal A type was relatively common(40.0%),while the HER2 overexpression type was the rarest(15.0%).Among different molecular subtypes,the differences in the marginal burr,calcification and posterior echo of the mass were statistically significant(P＜0.05),among which the Luminal A type and Luminal B type mainly showed marginal spiculate(79.2%,55.3%),the triple-negative type mainly showed enhancement or with no change(91.7%),and HER2 overexpression type mainly showed calcification(88.9%).However,there was no statistical significance in the maximum diameter,the orientation,the aspect ratio,the shape,the boundary,internal echo,the blood flow grade,and the elasticity score of the mass(P＞0.05).Conclusion:The ultrasound sonographic characteristics of young female patients with breast cancer are associated with their molecular subtypes,which can provide a valuable reference for predicting the molecular subtypes of breast cancers before a surgery.
基金项目
江苏省科学技术厅社会发展面上项目(BE2022789)
江苏省第六期"333高层次人才培养工程"(2022-3-25-069)
江苏省中医院创新发展项目(Y2021ZR06)
维普
万方数据