Gliomas are highly malignant tumors of the brain with poor prognosis.The standard treatment for gliomas is maximal surgical resection with adjuvant radiotherapy and chemotherapy.Due to the existence of"brain drift"in craniotomy and the need to protect the functional brain area,intraoperative ultrasound plays the role of real-time navigation and localization,assisting in determining the boundary of the tumor and identifying residual foci.The introduction of contrasted-enhanced ultrasound and artificial intelligence technology has demonstrated a promising application prospect for rapid molecular pathology diagnosis.Meanwhile,ultrasound-responsive nanosystems have the dual effects of temporarily opening the blood-brain barrier and precisely controlling drug release,and have demonstrated excellent biocompatibility and high specificity for gliomas.This article reviewed the research progress in both clinical and basic aspects mentioned above,providing new references for the diagnosis and treatment of glioma.
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