Prostate specific membrane antigen(PSMA)was first discovered in prostate cancer cells and is an important target for the diagnosis and treatment of tumors with high expression of PSMA such as prostate cancer.The development and application of a variety of imaging and therapeutic radionuclide-labeled targeted PSMA ligands play an important role in the theranostics of prostate cancer.This article reviewed the relevant research and clinical applications theranostics of PSMA.