肿瘤影像学2024，Vol.33Issue(5) ：493-500.DOI:10.19732/j.cnki.2096-6210.2024.05.005

68Ga-FAPI-04 PET/CT在腹部肿瘤多时间点扫描中的图像质量对比及其临床应用价值研究

Comparison of image quality and clinical application value of 68Ga-FAPI-04 PET/CT in multi-time point scanning of abdominal tumors

章泽宇 崔斌 汪建华 王胜利 张英英 梁思雨 程超 左长京
肿瘤影像学2024，Vol.33Issue(5) ：493-500.DOI:10.19732/j.cnki.2096-6210.2024.05.005
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68Ga-FAPI-04 PET/CT在腹部肿瘤多时间点扫描中的图像质量对比及其临床应用价值研究

Comparison of image quality and clinical application value of 68Ga-FAPI-04 PET/CT in multi-time point scanning of abdominal tumors

章泽宇 1崔斌 1汪建华 2王胜利 3张英英 1梁思雨 1程超 1左长京1
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作者信息

  • 1. 海军军医大学第一附属医院上海长海医院核医学科,上海 200433
  • 2. 厦门大学附属第一医院放射科,福建 厦门 361003
  • 3. 中国科学院上海应用物理研究所,上海 201800
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摘要

目的:本研究旨在探讨68Ga-成纤维细胞活化蛋白抑制剂(fibroblast activation protein inhibitor,FAPI)-04正电子发射体层成像(positron emission tomography,PET)/计算机体层成像(computed tomography,CT)显像的最佳扫描时间点,并评估肿瘤与阻塞性炎症中68Ga-FAPI-04药代动力学的差异.方法:回顾并分析2021年1-11月因腹部肿瘤在海军军医大学第一附属医院接受68Ga-FAPI-04 PET/CT显像的患者临床资料.利用Kruskal-Wallis H秩和检验比较各时间点肿瘤灶的最大标准摄取值(maximum standard uptake value,SUVmax)、肿瘤背景比值(tumor-to-background ratio,TBR)和图像信噪比(signal to noise ratio,SNR);通过Mann-Whitney U检验对肿瘤及阻塞性炎症的滞留指数(retention index,RI)进行差异分析.结果:本研究共纳入31例患者,在15 min、1 h和2 h肿瘤灶的SUVmax分别为8.52(4.18～18.4)、8.59(4.69～13.8)和7.64(3.22～21.0),对应的TBR为4.22(1.87～17.76)、4.67(2.20～29.05)和4.30(2.48～35.20).尽管1 h的SUVmax和TBR值高于其他时间点,但差异无统计学意义(P＞0.05).15 min、1 h和2 h的SNR分别为6.41(2.45～8.24)、5.0(1.68～5.57)和3.02(1.39～6.97),差异有统计学意义(H=51.691,P＜0.001),其中15 min的SNR最高.此外,15 min与1 h间肿瘤灶的RI显著高于阻塞性炎症(-0.195～0.415 vs-0.422～0.115),差异亦有统计学意义(P=0.018).结论:注射68Ga-FAPI-04后15 min的图像SNR最高,可作为临床常规扫描时间点.此外,15 min与1 h的RI可有效地用于区分肿瘤与阻塞性炎症.

Abstract

Objective:To determine the optimal scanning time point for 68Ga-fibroblast activation protein inhibitor(FAPI)-04 positron emission tomography(PET)/computed tomography(CT)imaging and to evaluate the differences in the pharmacokinetics of 68Ga-FAPI-04 between tumors and obstructive inflammation.Methods:A retrospective analysis of clinical data from patients who underwent 68Ga-FAPI-04 PET/CT imaging due to abdominal tumors in The First Affiliated Hospital of Naval Medical University between January and November 2021 was conducted.The maximum standard uptake value(SUVmax),tumor-to-background ratio(TBR),and signal-to-noise ratio(SNR)were compared across different time points using the Kruskal-Wallis H test,while the retention index(RI)for tumors and obstructive inflammation was analyzed using the Mann-Whitney U test.Results:A total of 31 patients were included in this study.The SUVmax values for tumor lesions at 15 min,1 h,and 2 h were 8.52(4.18-18.4),8.59(4.69-13.8),and 7.64(3.22-21.0),respectively,with corresponding TBR values of 4.22(1.87-17.76),4.67(2.20-29.05),and 4.30(2.48-35.20).Although the SUVmax and TBR at 1 h were higher than those at other time points,the differences were not statistically significant(P＞0.05).The SNR values at 15 min,1 h,and 2 h were 6.41(2.45-8.24),5.0(1.68-5.57),and 3.02(1.39-6.97),showing significant differences(H value:51.691,P＜0.001),with the highest SNR observed at 15 min.Furthermore,the RI for tumors at 15 min and 1 h was significantly higher than that for obstructive inflammation(-0.195-0.415 vs-0.422-0.115),with a statistically significant difference(P=0.018).Conclusion:The image SNR is highest at 15 min after the injection of 68Ga-FAP1-04,making it a suitable time point for routine clinical scanning.Additionally,the RI at 15 min and 1 h is beneficial for distinguishing between tumors and obstructive inflammation.

关键词

68Ga-成纤维细胞活化蛋白抑制剂/腹部肿瘤/正电子发射体层成像/计算机体层成像/信噪比/滞留指数

Key words

68Ga-labeled fibroblast activation protein inhibitor/Abdominal tumor/Positron emission tomography/computed tomography/Signal to noise ratio/Retention index

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基金项目

上海市卫生健康委员会新兴交叉领域研究专项(2022JC004)

海军军医大学第一附属医院"十四五"学科固海计划(GH145-22)

出版年

2024
肿瘤影像学
复旦大学附属肿瘤医院

肿瘤影像学

CSTPCD
影响因子：0.67
ISSN：1008-617X
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