s]Objective:To investigate the radiation levels around patients with gastroenteropancreatic neuroendocrine neoplasm(GEP-NEN)at different times after treatment with 177Lu-DOTATATE,and to provide a reference for radiation safety and patient management.Methods:GEP-NEN patients who were hospitalized for 177Lu-DOTATATE in Fudan University Shanghai Cancer Center from May to November 2023 were selected as the research subjects.These patients were treated with a single intravenous dose of(7 618.5±241.9)MBq of 177Lu-DOTATATE.At different time points after administration,the peripheral dose equivalent rate at 1 m in front of the patient was measured,and the change pattern of the peripheral dose equivalent rate over time was analyzed.Results:A total of 78 177Lu-DOTATATE treatments were performed in 30 GEP-NEN patients.Immediately after the end of administration,the average dose equivalent rate at 1 m in front of the patient was 20.0 μSv/h.The peripheral dose equivalent rate decayed exponentially with time,and the average time it dropped to 10 μSv/h was 3.95 h,and the upper limit of the 95%CI was 4.6 h.The effective half-life of the peripheral dose equivalent rate within 24 h was 1.42 h.Conclusion:After each 177Lu-DOTATATE treatment,the ambient dose equivalent rate decreased rapidly over time,and the ambient dose equivalent rate at 1 m dropped to 10 μSv/h at an average of 3.95 h.At 4.6 h,95%of the patients could drop below 10 μSv/h.This study provides experimental data and basis for the formulation of discharge criteria or patient management for patients treated with 177Lu-DOTATATE in China.
万方数据