Effects of acupuncture-moxibustion on pregnancy outcomes and sleep disturbance after repeated implantation failure
Objective To observe the clinical efficacy of stage-based acupuncture-moxibustion for infertility after repeated implantation failure(RIF)and the effects on the patient's endometrial receptivity and sleep disturbance.Method Ninety patients suffering from infertility after RIF were randomized into an observation group and a control group,each consisting of 45 cases.The control group received assisted reproduction intervention with gonadotrophin-releasing hormone agonist(GnRH-a)down-regulation plus artificial cycle regimen,based on which the observation group additionally received stage-based acupuncture-moxibustion treatment.Before and after the treatment,the two groups were observed for changes in the endometrial thickness and classification,uterine artery blood flow indicators[pulsatility index(PI),resistance index(RI),and peak systolic velocity/end diastolic velocity(S/D)];the score of Pittsburgh sleep quality index(PSQI)was compared before and after the treatment.The clinical efficacy was also compared between the two groups.Result The endometrial classification changed significantly in each group after the treatment(P＜0.05),and the between-group difference also showed statistical significance(P＜0.05).After the treatment,the endometrial thickness and uterine artery blood flow indicators changed markedly in each group(P＜0.05)and differed significantly between the two groups(P＜0.05).After the intervention,there was a significant change in the PSQI score in both groups(P＜0.05),and the score was lower in the observation group than in the control group(P＜0.05).The observation group had a higher clinical pregnancy rate compared to the control group(P＜0.05).Conclusion Based on the GnRH-a down-regulation plus artificial cycle regimen,stage-based acupuncture-moxibus-tion can improve the endometrial receptivity in infertility after RIF patients and enhance their sleep quality and clinical pregnancy rate.
万方数据
维普
