Observation on the efficacy of point injection combined with chemotherapy in the treatment of intermediate and advanced non-small cell lung cancer and its effect on patients'bone marrow suppression and immune function
Objective To observe the effects of point injection combined with moxibustion on myelosuppression and immune function of patients with middle-and late-stage non-small cell lung cancer(NSCLC)on the basis of chemotherapy,and to evaluate its near-and long-term therapeutic effects.Method Eighty patients with stage Ⅲ B orⅣ NSCLC were selected and randomly assigned into chemotherapy group and combination group,with 40 cases in each group.The chemotherapy group was treated with systemic chemotherapy,while the combination group was treated with mild moxibustion and point injection of Shenqi injection on the basis of chemotherapy.The Karnofsky performance status(KPS)scores,myelosuppressive indexes[white blood cell(WBC),hemoglobin(Hb),platelet(PLT)and neutrophil(NEUT)],serum factors[interleukin-3(IL-3),interleukin-6(IL-6),erythropoietin(EPO),granulocyte-macrophage stimulating factor(GM-CSF)]and cellular immunity indexes(peripheral blood CD3﹢,CD4﹢,CD8﹢ T-cell ratio and CD4﹢/CD8﹢ ratio)were observed before and after treatment in both groups,and the short-term efficacy,long-term efficacy,and efficacy of Chinese medicine major symptoms were compared in the two groups.Result The overall remission rate was 67.5% in the combination group and 45.0% in the chemotherapy group,and the overall remission rate was higher in the combination group than in the chemotherapy group(P＜0.05);the median survival period was longer in the combination group than that in the chemotherapy group(P＜0.05),and the 1-year survival rate in the combination group was higher than that in the chemotherapy group(P＜0.05).The total effective rate was 92.5% in the combination group and 77.5% in the chemotherapy group,and the total effective rate was higher in the combination group than in the chemotherapy group(P＜0.05).The KPS scores of both groups were higher than those before treatment(P＜0.05),and those in the combination group were higher than those in the chemotherapy group(P＜0.05).Peripheral blood WBC,PLT and NEUT counts and Hb concentration were significantly lower in both groups after treatment compared with those before treatment(P＜0.05),and those in t he combination group were higher than those in the chemotherapy group(P＜0.05).Serum IL-3,IL-6,EPO and GM-CSF levels were significantly reduced in both groups after treatment compared with those before treatment(P＜0.05);and those in the combination group was higher than those in the chemotherapy group(P＜0.05).In the combination group,the peripheral blood CD3﹢,CD4﹢T-cell ratio and CD4﹢/CD8﹢ ratio were significantly higher than those before treatment(P＜0.05),and the CD8﹢T-cell ratio was significantly lower than that before treatment(P＜0.05);in the chemotherapy group,the peripheral blood CD3﹢,CD4﹢ and CD8﹢ T-cell ratios and the CD4﹢/CD8﹢ ratio were significantly lower than those before treatment(P＜0.05);the peripheral blood CD3﹢,CD4﹢,CD8﹢ T cell ratios and CD4﹢/CD8﹢ ratios in the combination group were significantly higher than those in the chemotherapy group,and the CD8﹢ T cell ratios were significantly lower than those in the chemotherapy group(P＜0.05).Conclusion The combination of point injection and moxibustion on the basis of chemotherapy can effectively improve the survival rate,delay disease progression,reduce the symptoms of myelosuppression and immune function caused by chemotherapy,and its mechanism of action may be related to the promotion of hematopoietic factor production.
Acupuncture-moxibustion therapyHydro-acupunctureMoxa stick moxibustionAcupuncture-medication combinedCarcinoma,Non-small-cell lungMyelosuppressionImmune function
维普
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