Clinical observation of lung protection of acupuncture-drug compound anesthesia in thoracoscopic lung cancer surgery
Objective:To observe the lung protective effect of acupuncture-drug compound anesthesia in thoracoscopic lung cancer surgery,and verify the effect of acupunctur-drug compound anesthesia on reducing postoperative lung injury and improving prognosis in patients undergoing thoracoscopic lung cancer surgery.Methods:A randomized,controlled method was applied.A total of 70 patients undergoing elective thoracoscopic radical resection for lung cancer were randomly divided into the acupuncture-drug compound anesthesia group and the general anesthesia group,35 cases in each group.The patients in the general anesthesia group underwent routine general anesthesia.The patients in the acupuncture-drug compound anesthesia group received electroacupuncture intervention 30 min before anesthesia induction,and then received conventional anesthesia induction,the dose of anesthetic was 1/3 of conventional anesthesia.The levels of oxygenation index,and serum interleukin(IL)-2,IL-6,IL-10 and tumor necrosis factor-α(TNF-α)were detected and compared between the two groups before surgery,immediately after surgery,8 h after surgery and the next day after surgery.The postoperative drainage amount,postoperative antibiotic use days,postoperative hospitalization days and the total medical costs of the two groups were compared.Results:① After surgery,the oxygenation index levels in both groups were increased(P＜0.05),and 8 h after surgery,the oxygenation index level of the acupuncture-drug compound anesthesia group was higher than that of the general anesthesia group(P＜0.05).② Eight hours after surgery,the level of IL-2 in the acupuncture-drug compound anesthesia group was higher than that in the general anesthesia group(P＜0.05).After surgery,the levels of IL-6 in both groups were increased compared with those before surgery(P＜0.05),but immediately after surgery,the level of IL-6 in the acupuncture-drug compound anesthesia group was lower than that in the general anesthesia group(P＜0.05).After surgery,the levels of IL-10 in both groups were increased compared with those before surgery(P＜0.05),but there was no statistically significant difference between the two groups(P＞0.05).③Compared with the general anesthesia group,the postoperative antibiotic use days and postoperative hospitalization days of the acupuncture-drug compound anesthesia group were shortened(P＜0.05,P＜0.01),and the total medical costs were decreased(P＜0.05).Conclusion:Acupuncture-drug compound anesthesia can improve the postoperative inflammatory response and immune function in patients undergoing thoracoscopic lung cancer surgery,thus reduces the postoperative lung injury and improves the oxygenation function of lung,and has a certain protective effect on lung function for patients in perioperative period.
万方数据
维普
