Research progress of Poria and its compound formulas against glucolipid metabolic disorders
Poria is known as"Poria is used for nine times in ten drugs".It has been used as drug for a long history,and has the effects of promoting urination and draining dampness,strengthening spleen and calming heart.Clinically,it is frequently used to treat many symptoms,such as oliguria due to edema,phlegm-rheum dizziness,sloppy stool and diarrhea,disquieted heart spirit,fright palpitation and insomnia.Polysaccharides and triterpenes are the main chemical components of Poria,which has a wide range of pharmacological activities,such as diuresis,anti-tumor,immunity enhancing,anti-inflammatory,hepatoprotection,blood lipid lowering,blood sugar lowering,sedation and hypnosis,antiviral,anti-oxidant,anti-fatigue,anti-coagulation and lithiasis prevention.Glucolipid metabolic disorders(GLMD)is a serious threat to human health.Poria can simultaneously regulate the disorders of glucose and lipid metabolism through multi-pathways and multi-targets,due to its complex and diverse chemical composition.Moreover,as a medicine and food homologous traditional Chinese medicine with high safety,Poria is commonly used to prevent and treat GLMD-related diseases in clinical practice.This article reviewed the traditional Chinese medicine perspective and investigation on modern pharmacological effects,pharmacodynamic substances and compatibility of Poria for GLMD treatment.Furthermore,the existing problems and prospects were also proposed.
Poriaglucose and lipid metabolismpathogenesis of Chinese medicinepharmacological researcheffective substancescompatibility
万方数据
维普
