Resistance mechanism of targeted drugs in metastatic colorectal cancer and therapeutic strategies of traditional Chinese medicine
Molecular targeted therapy is one of the main treatment options for metastatic colorectal cancer(mCRC),and combined with chemotherapy,it can provide significant benefits in patients'overall survival(OS)and progression-free survival(PFS).Commonly used molecular targeted drugs in clinic mainly includes small molecule signal transduction inhibitors and large molecule monoclonal antibodies.However,the problem of drug resistance in the later stage of targeted therapy becomes a key challenge for clinic treatment.Studies have shown that the mechanism of targeted drug resistance may be related to a variety of factors,including abnormalities in related cell signaling pathways such as epidermal growth factor receptor(EGFR),vascular endothelial growth factor(VEGF),human epidermal growth factor receptor 2(HER2)and alterations in tumor microenvironment.In recent years,studies have found that traditional Chinese medicine are quite effective in reversing targeted drug resistance.Therefore,this article discusses the mechanisms of drug resistance to molecular targeted therapy in CRC,as well as the coping strategies of traditional Chinese medicine,and discusses the tradional Chinese medicine and its active ingredients that can reverse targeted drug resistance.
targeted therapycolorectal cancerdrug resistancetraditional Chinese medicine
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