Mechanism of electroacupuncture inhibiting microglia activation mediating chronic pain analgesia
Chronic pain is one of the most difficult diseases to cure in the world.In the past,it was thought that the appearance of chronic pain was only related to the plasticity of neurons,but now more and more attention has been paid to the important involvement of non-neuronal cells,especially microglia.Electroacupuncture has gradually become an alternative therapy for chronic pain due to its safety and effectiveness,and its analgesic effect can be achieved by inhibiting the overactivation of microglia.Based on the regulation effect of electroacupuncture on the microglia activation in chronic pain,the analgesic mechanism of electroacupuncture is discussed,in order to provide a basis for the effectiveness of clinical electroacupuncture analgesia.