首页|电针抑制小胶质细胞活化介导慢性疼痛镇痛的作用机制

电针抑制小胶质细胞活化介导慢性疼痛镇痛的作用机制

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慢性疼痛是目前世界上最难治愈的疾病之一,过往认为其产生仅与神经元的可塑性有关,而现在越来越关注到非神经元细胞特别是小胶质细胞的重要参与作用.电针因其安全有效性已逐渐成为慢性疼痛的一种替代疗法,其镇痛作用可通过抑制小胶质细胞的过度活化实现.以电针对慢性疼痛中小胶质细胞活化的调控作用为基点,探讨电针的镇痛作用机制,以期为临床电针镇痛的有效性提供依据.
Mechanism of electroacupuncture inhibiting microglia activation mediating chronic pain analgesia
Chronic pain is one of the most difficult diseases to cure in the world.In the past,it was thought that the appearance of chronic pain was only related to the plasticity of neurons,but now more and more attention has been paid to the important involvement of non-neuronal cells,especially microglia.Electroacupuncture has gradually become an alternative therapy for chronic pain due to its safety and effectiveness,and its analgesic effect can be achieved by inhibiting the overactivation of microglia.Based on the regulation effect of electroacupuncture on the microglia activation in chronic pain,the analgesic mechanism of electroacupuncture is discussed,in order to provide a basis for the effectiveness of clinical electroacupuncture analgesia.

chronic painelectroacupunctureanalgesiamicrogliaglial reaction

梁嘉仪、顾意鸣、王功命、孟想、夏勇、王珂、具紫勇

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上海中医药大学针灸推拿学院(上海 201203)

上海中医药大学附属岳阳中西医结合医院(上海 200437)

慢性疼痛 电针 镇痛 小胶质细胞 神经胶质反应

国家自然科学基金

81874506

2024

上海中医药大学学报
上海中医药大学,上海市中医药研究院

上海中医药大学学报

CSTPCD
影响因子:0.788
ISSN:1008-861X
年,卷(期):2024.38(2)
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