薏苡附子败酱散干预结肠"炎-癌"转化的研究概况
Research progress on intervention of Yiyi Fuzi Baijiang Powder in colitis-to-colorectal-cancer transformation
杨福芹 1周晟 1刘俊珊 2周兴旺 3邓丽娟1
作者信息
- 1. 暨南大学中医学院方证研究中心(广东 广州 510632)
- 2. 南方医科大学中医药学院(广东 广州 510000)
- 3. 中山大学中山医学院生化与分子生物学系(广东 广州 510275)
- 折叠
摘要
结肠"炎-癌"转化是指炎症性肠病逐步向结直肠癌(CRC)发展的过程.虚-湿-毒与CRC发生发展密切相关,虚-湿-毒影响肿瘤微环境促进肿瘤生长,同时也是结肠"炎-癌"转化的重要病因病机.薏苡附子败酱散具有祛湿解毒消痈、补虚助阳驱邪之功,可延缓因虚-湿-毒引起的结肠"炎-癌"转化的进程.故课题组对结肠"炎-癌"转化、肿瘤微环境的作用、中医对结肠"炎-癌"转化的认识,特别是薏苡附子败酱散干预结肠"炎-癌"转化的过程进行评述,以期为其治疗结肠相关疾病提供新思路.
Abstract
Colitis-to-colorectal-cancer transformation refers to the gradual development from inflammatory bowel disease into colorectal cancer(CRC)."Deficiency-dampness-toxin"is closely related to the occurrence and development of CRC."Deficiency-dampness-toxin"affects the microenvironment of tumor and promotes tumor growth,and it is also an important etiology and pathogenesis for the colitis-to-colorectal-cancer transformation.Yiyi Fuzi Baijiang Powder has the function of eliminating dampness,removing toxin and resolving abscess,tonifying deficiency,replenishing yang and removing pathogenic factors,which can delay the process of colitis-to-colon-cancer transformation caused by"deficiency-dampness-toxin".Therefore,the research group reviewed colitis-to-colorectal-cancer transformation,the role of tumor microenvironment,the understanding of Chinese medicine on colitis-to-colorectal-cancer transformation,especially the process of Yiyi Fuzi Baijiang Powder intervening in colitis-to-colon-cancer transformation,in order to provide new ideas for the treatment of colorectal-related diseases.
关键词
薏苡附子败酱散/结肠炎/结直肠癌/"炎-癌"转化Key words
Yiyi Fuzi Baijiang Powder/colitis/colorectal cancer/inflammation-cancer transformation引用本文复制引用
基金项目
广东省自然科学基金青年提升项目(2023A1515030276)
广州市科技局基础研究计划一般项目(202201011498)
广东省基础和应用基础研究基金(2019B1515120051)
出版年
2024
NETL
NSTL
万方数据