Research progress of traditional Chinese medicine regulating NLRP3 inflammasome in treatment of multiple organ damage in sepsis
Sepsis is a systemic inflammatory response caused by the dysregulations of host immune response to infection,leading to life-threatening organ dysfunction.The nucleotide binding oligomerization domain(Nod)-like receptor protein 3(NLRP3)inflammasome plays an important role in the innate immune system.Studies have shown that activation of the NLRP3 inflammasome can lead to further aggravation of systemic inflammation during the process of multiple organ damage in sepsis.Therefore,it is crucial to elucidate the activation mechanism of NLRP3 inflammasome and its pathogenic role in multiple organ damage in sepsis.This article will review the latest progress of the above research,and elaborate the therapeutic effect of traditional Chinese medicine on sepsis from the perspective of NLRP3 inflammasome,so as to provide some references for the treatment of multiple organ damage in sepsis.
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