首页|定眩舒郁方治疗阴虚阳亢型高血压合并焦虑状态的临床观察

定眩舒郁方治疗阴虚阳亢型高血压合并焦虑状态的临床观察

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目的:观察定眩舒郁方治疗高血压合并焦虑状态患者的临床疗效.方法:纳入74例阴虚阳亢型高血压合并焦虑状态且对抗焦虑药不耐受的患者,随机分为治疗组和对照组,每组各37例.两组患者均给予常规降压药治疗,在此基础上,治疗组患者给予定眩舒郁方口服,对照组患者给予安慰剂口服,疗程均为4周.治疗前后,评价并比较两组患者的广泛性焦虑障碍量表(GAD-7)、汉密尔顿焦虑量表(HAMA)、睡眠状况自评量表(SRSS)评分及中医证候总积分;检测两组患者的收缩压与舒张压水平.结果:治疗后,治疗组患者的GAD-7、HAMA、SRSS评分及中医证候总积分较治疗前均显著降低(P＜0.01),且低于对照组(P＜0.01);同时,治疗组患者的收缩压、舒张压水平较治疗前亦降低(P＜0.05),且低于对照组(P＜0.05).结论:定眩舒郁方治疗高血压合并焦虑状态具有较好的临床疗效,可改善患者的焦虑情绪和中医证候,降低患者的血压,且安全性良好.
Clinical observation of Dingxuan Shuyu Formula in treatment of hypertension combined with anxiety of yin-deficiency and yang-hyperactivity type
Objective:To observe the clinical effect of Dingxuan Shuyu Decoction in treating patients of hypertension combined with anxiety.Methods:A total of 74 patients of hypertension combined with anxiety with type of yin-deficiency and yang-hyperactivity,who were intolerance to anxiolytics,were included,and randomly divided into treatment group and a control group,37 cases in each group.The patients in both groups were given conventional antihypertensive drugs.Based on above,the patients in the treatment group were orally treated with Dingxuan Shuyu Formula,and the patients in the control group were orally treated with placebo,with a course of 4 weeks.Before and after treatment,the scores of Generalized Anxiety Disorder-7(GAD-7),Hamilton Anxiety Scale(HAMA)and self-rating sleep scale(SRSS),and the total scores of traditional Chinese Medicine syndrome in the two groups were evaluated and compared,and the levels of systolic and diastolic blood pressure of the patients in both groups were detected.Results:After treatment,the scores of GAD-7,HAMA and SRSS,and the total scores of traditional Chinese medicine syndrome in the treatment group were significantly decreased compared with those before treatment(P＜0.01),and were lower than those in the control group(P＜0.01).Meanwhile,the levels of systolic and diastolic blood pressure in the treatment group were also decreased compared with those before treatment(P＜0.05),and were lower than those in the control group(P＜0.05).Conclusion:Dingxuan Shuyu Formula has good clinical effect in the treatment of hypertension combined with anxiety.It can improve the anxiety and traditional Chinese medicine syndrome of the patients,and decrease the blood pressure,with good safety.

hypertensionanxiety stateinsomniaDingxuan Shuyu Formulaintegrated traditional Chinese and western medicine

陶丽宇、方蔓倩、陆灏

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上海中医药大学附属曙光医院老年医学科(上海 200021)

上海中医药大学附属曙光医院内分泌科(上海 200021)

高血压 焦虑状态 失眠 定眩舒郁方 中西医结合

上海市科委中医临床重点实验室项目上海市卫健委中医药科研项目上海市中医药学会"凯宝"青年医师海派中医传承研究项目上海市进一步加快中医药传承创新发展三年行动计划项目

20DZ22722002020LQ0132023-HPZY-02ZY[2021-2023]-0302

2024

10.16306/j.1008-861x.2024.03.005

上海中医药大学学报
上海中医药大学,上海市中医药研究院

上海中医药大学学报

CSTPCD
影响因子：0.788
ISSN：1008-861X
年,卷(期)：2024.38(3)
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