Study on preparation technology and transdermal experiment of compound Sanguisorbae Radix gel plaster
Objective:To prepare compound Sanguisorbae Radix extract gel plaster,and study its transdermal and release characteristics in vitro.Methods:The matrix formulation of gel plaster was optimized by orthogonal experiment.Franz diffusion cells and semipermeable membrane were used for in vitro percutaneous penetration and in vitro release experiments.Taking gallic acid,the main active component of Sanguisorbae Radix,as the detection indicator,and was analyzed and determined by high-performance liquid chromatography.Results:The optimal matrix formulation of gel plaster was 2.5 g sodium polyacrylate NP700,1.5 g polyvinylpyrrolidone-K30(PVP-K30),4g carboxymethyl cellulose-Natrium(CMC-Na)and 1g carbomer.The sample preparation process of this experimental scheme was controllable,with good repeatability,stability and recovery rate.The transdermal rate of gallic acid,the main component of compound Sanguisorbae Radix gel plaster,was 4.783 μg·cm-2·h-1,and the drug release rate was 5.89 μg·cm-2·h-1.Conclusions:The prepared matrix structure of the compound Sanguisorbae Radix gel plaster had good compatibility with the compound Sanguisorbae Radix extract.The drug release rate of gallic acid was higher than the transdermal rate,which means the skin barrier played a speed limiting role.
Sanguisorbae Radixgel plastertraditional Chinese medicinetechnology
万方数据
维普
