Research progress and coping strategies of Chinese materia medica induced cardiotoxicity
With the continuous emphasis on traditional Chinese medicine(TCM),the safety evaluation and incidence of adverse events in Chinese materia medica has been increasingly concerned.Chinese materia medica induced cardiotoxicity refers to acute or chronic damage to cardiac function or cardiomyocytes,which is highly hazardous and lethal.Therefore,it is of great significance for early assessment of cardiotoxicity induced by Chinese materia medica,identification of toxic components and their mechanisms of action,and search for means to reduce toxicity and increase efficacy to reduce cardiac injury and improve safety of Chinese materia medica,and promote TCM development.The paper aims to summarize current research difficulties and diagnosis-treatment-prevention strategies in this field,meanwhile focusing on drug factors,list main Chinese herbal medicinal ingredients with confirmed or potential cardiotoxicity and their toxicity mechanisms,propose to strengthen the pharmacological and toxicological research on Chinese materia medica with both efficacy and toxicity,and gradually figure out the law of"dose-effect-toxicity"to maximize the efficacy of Chinese materia medica,so as to jointly establish the safety assessment and prevention system of cardiotoxicity of Chinese materia medica and promote the modernization development of Chinese medicine.
Chinese material medicacardiotoxicitytoxic mechanismsafety of Chinese materia medica
万方数据
维普
