Effect of acupuncture therapy on cortical activation in stroke patients with hemiplegia based on fNIRS
Objective:To observe the cortical specific activation response characteristics induced by limb acupuncture in stroke hemiplegic patients based on functional near-infrared spectroscopy(fNIRS),and preliminarily explore the possible neural mechanisms of acupuncture therapy.Methods:Nineteen stroke hemiplegic patients were included,who were divided into the relatively mildly impaired group(MI group,10 cases)and relatively severely impaired group(SI group,9 cases)according to the severity of motor dysfunction.All the patients were intervened by acupuncture on the affected side limb.In the resting state before acupuncture and during the acupuncture course,the cerebral blood oxygen parameters in the bilateral prefrontal and motor-related cortex of the patients were detected by 32-channel fNIRS system,and the interested oscillation amplitude in the fNIRS signal was calculated by time-frequency analysis method,in order to analyze the response characteristics of brain activation induced by limb acupuncture.Through intra-group and inter-group comparisons,the specific response characteristics of brain function induced by acupuncture in patients with different severity of movement disorders were focused on.Results:The results of intra-group analysis showed that,compared with the resting state,the activation response of Channel(Ch)26 in the motor cortex of non-affected side was significantly increased in the MI group in the acupuncture state(P＜0.05);in the acupuncture state,the activation responses of Ch1,Ch3,Ch5,Ch14 and Ch15 in the frontal lobe and motor area of affected side were significantly increased in SI group(P＜0.05),and the activation responses of Ch 11 and Ch23 in the frontal lobe and motor area of non-affected side were also significantly increased(P＜0.05).The results of inter-group analysis showed that,the cortical activation responses of Ch11,Ch 13,Ch24 and Ch25 induced by acupuncture in the SI group were significantly higher than those in the MI group.The results of correlation analysis showed that,the activation changes in the frontal lobe and motor area cortex induced by acupuncture in the MI group were significantly negatively correlated with the upper and lower limb motor function performance of the patients.Conclusion:Acupuncture can induce a bilateral brain activation response in stroke hemiplegic patients,and the cortical activation responses in the acupuncture state of the patients with severely impaired motor function were more significant than those of the patients with mildly impaired motor function,especially in the affected hemisphere.
stroke hemiplegiaacupuncturebrain function imagingactivation responserehabilitation of traditional Chinese medicine
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