A randomized controlled clinical study on Yantiao Formula in improving inflammatory indicators in elderly patients with acute cholecystitis after PTGD
Objective:To explore the clinical efficacy of Yantiao Formula(YTF)in treating elderly patients with acute cholecystitis(AC)after percutaneous transhepatic gallbladder drainage(PTGD).Methods:A randomized,single-blind,placebo-controlled clinical study was conducted.A total of 72 elderly patients with AC undergoing PTGD were included and randomly divided into a control group and a treatment group,36 cases in each group.All the patients were given routine intervention after PTGD.Based on above,the patients in the control group were treated with YTF placebo orally,and the patients in the treatment group were treated with YTF orally,with a treatment course of 4 weeks.Before and after treatment,the levels of inflammatory response indicators[including white blood cell count(WBC),neutrophil percentage(N%),C-reactive protein(CRP),procalcitonin(PCT),interleukin(IL)-6],and liver function indicators[including total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),gamma-glutamyl transpeptidase(GGT),prothrombin time(PT)]were detected and compared,and the total scores of traditional Chinese medicine clinical symptoms were compared between the two groups.Results:During the trial,4 patients in the control group and 6 patients in the treatment group were excluded.Finally,32 cases in the control group and 30 cases in the treatment group were included in the statistical analysis.①After treatment,the levels of WBC,N%,CRP,PCT and IL-6 in both groups were significantly decreased compared with those before treatment(P<0.05),and the levels of CRP,PCT and IL-6 in the treatment group were lower than those in the control group(P<0.05).②After treatment,the levels of TBIL and PT in both groups were significantly decreased compared with those before treatment(P<0.05),but there were no statistically significant differences between the two groups(P>0.05).③After treatment,the total scores of traditional Chinese medicine clinical symptoms in both groups were significantly decreased compared with those before treatment(P<0.01),and the total score of the treatment group was lower than that of the control group(P<0.05).Conclusion:Oral administration of YTF can further alleviate the inflammation response after gallbladder puncture and improve the clinical symptoms in elderly patients with AC after PTGD,which is worthy of clinical promotion and application.
acute cholecystitispercutaneous transhepatic gallbladder drainageYantiao Formulainflammatory indicatorsintegrated traditional Chinese and western medicine