Clinical study on Xintongning Granules in treating non-ST-segment elevation acute coronary syndrome with qi deficiency and phlegm stasis syndrome
Objective:To observe the clinical efficacy of Xintongning Granules in treating non-ST-segment elevation acute coronary syndrome(NSTE-ACS)with qi deficiency and phlegm stasis syndrome.Methods:A randomized,double-blind,placebo-controlled method was applied in this study.One hundred patients of NSTE-ACS with qi deficiency and phlegm stasis syndrome were divided into the treatment group(50 cases)and control group(50 cases).The patients in the treatment group were treated with Xintongning Granules combined with conventional western medicine,and the patients in the control group were treated with placebo granules combined with conventional western medicine,with a course of 12 weeks.Before treatment and after 4,8 and 12 weeks of treatment,the angina pectoris symptom scores and the total scores of traditional Chinese medicine(TCM)syndrome were compared between the two groups.After 4,8 and 12 weeks of treatment,the therapeutic efficacy of angina pectoris,the therapeutic efficacy of TCM syndrome,and the nitroglycerin reduction rate in both groups were evaluated.After 12 weeks of treatment,the therapeutic efficacy of electrocardiogram was compared between the two groups.Before treatment and after 12 weeks of treatment,the left ventricular ejection fraction(LVEF)of patients in the two groups was detected and compared.Results:①After 4,8 and 12 weeks of treatment,the symptom scores of angina pectoris in both groups were significantly decreased compared with those before treatment(P<0.01),and after 8 and 12 weeks of treatment,the symptom scores of angina pectoris in the treatment group were lower than those in the control group(P<0.05,P<0.01).②After 8 and 12 weeks of treatment,the therapeutic efficacy of angina pectoris in the treatment group was superior to the control group(P<0.01),and the nitroglycerin reduction rate was significantly higher than that in the control group(P<0.05).③After 4,8 and 12 weeks of treatment,the total scores of TCM syndrome in both groups were significantly decreased compared with those before treatment(P<0.01),and after 8 and 12 weeks of treatment,the total scores of TCM syndrome in the treatment group were significantly lower than those in the control group(P<0.01).④After 4,8 and 12 weeks of treatment,the therapeutic efficacy of TCM syndrome in the treatment group was superior to the control group(P<0.05,P<0.01).⑤After 12 weeks of treatment,the therapeutic efficacy of electrocardiogram in the treatment group was superior to the control group(P<0.05).⑥After 12 weeks of treatment,the level of LVEF in the treatment group was increased compared with that before treatment(P<0.01),and was higher than that in the control group(P<0.05).Conclusion:Xintongning Granules combined with conventional western medicine can effectively alleviate the clinical symptoms of NSTE-ACS patients with qi deficiency and phlegm stasis syndrome,improve the cardiac function,and enhance the clinical efficacy.
non-ST-segment elevation acute coronary syndromeqi deficiency and phlegm stasis syndromeXintongning Granulesintegrated traditional Chinese and western medicine
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