Effect of Shenshuai Ⅱ Formula on bone metabolism in patients with CKD at stages 3-5 complicated with MBD based on theory of"kidney governs bone and generates marrow"
Objective:To observe the effect of Shenshuai Ⅱ Formula on bone metabolism in patients with chronic kidney disease(CKD)at stages 3-5 complicated with mineral and bone disorder(MBD).Methods:202 patients with CKD at stages 3-5 complicated with MBD were included and randomly divided into the control group(100 cases)and experimental group(102 cases).The patients in the control group were treated with integrated western medicine and calcitriol soft capsules orally,and the patients in the experimental group were treated with Shenshuai Ⅱ Formula orally based on the treatment of the control group.The treatment course of both groups was 3 months.Before and after treatment,the levels of indexes of renal function and bone metabolism in the two groups were detected and compared,and the specific indexes included vitamin D(VD),25-hydroxyvitamin D2(25OH-VD2),25-hydroxyvitamin D3(25OH-VD3),parathyroid hormone(PTH),β-bone collagen sequence(β-Crossl Laps),albumin(Alb),alkaline phosphatase(ALP),total calcium,corrected calcium,serum inorganic phosphorus(IP),serum creatinine(Scr),blood urea nitrogen(BUN),and glomerular filtration rate(eGFR).Results:During the treatment,two patients in the control group were removed,and one patient in the experimental group fell out.Finally,98 cases in the control group and 101 cases in the experimental group were included in the statistical analysis.①After treatment,the levels of Scr and BUN in the two groups were significantly decreased compared with those before treatment(P<0.05),the level of eGFR was significantly increased compared with that before treatment(P<0.05),and the levels of Scr and BUN in the experimental group were lower than those in the control group(P<0.05),the level of eGFR was higher than that in the control group(P<0.05).②After treatment,the levels of 25OH-VD2,25OH-VD3,ALP,total calcium and corrected calcium in the two groups were significantly increased compared with those before treatment(P<0.05),the levels of PTH,β-Crossl Laps and IP were significantly decreased compared with those before treatment(P<0.05),the level of Alb in the experimental group was also increased compared with that before treatment(P<0.05),and the levels of 25OH-VD2,ALP and total calcium in the experimental group were higher than those in the control group(P<0.05),the levels of PTH and IP were lower than those in the control group(P<0.05).Conclusion:Compared with conventional western medicine therapy,Shenshuai Ⅱ Formula combined with conventional western medicine can more significantly improve the renal function of patients with CKD at stages 3-5 complicated with MBD,significantly regulate the bone metabolism function of patients with advanced CKD,and thus improve the prognosis of patients.
chronic kidney diseasemineral and bone disorderShenshuai Ⅱ Formularenal functionbone metabolism
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