Clinical study on tonifying kidney,reducing phlegm and removing blood stasis method combined with physical exercise in treatment of overweight/obese polycystic ovary syndrome
Objective:To observe the clinical efficacy of tonifying kidney,reducing phlegm and removing blood stasis method combined with physical exercise in the treatment of overweight/obese polycystic ovary syndrome(PCOS).Methods:A total of 72 patients with overweight/obese PCOS were included and randomly divided into the treatment group and control group,36 cases in each group.The patients in the treatment group were treated with tonifying kidney,reducing phlegm and removing blood stasis formula combined with physical exercise,and the patients in the control group were treated with tonifying kidney,reducing phlegm and removing blood stasis formula,with a course of 3 months.The clinical efficacy was compared between the two groups.Before and after intervention,the menstrual condition scores,Ferriman-Gallwey hirsutism scores,acne grading scores,acanthosis nigricans scores,and Self-Rating Anxiety Scale(SAS)scores of both groups were evaluated and compared.Before and after intervention,the levels of sex hormones[including luteinizing hormone(LH),follicle-stimulating hormone(FSH),testosterone(T),anti-Müllerian hormone(AMH),and LH/FSH ratio],glucose and lipid metabolism indicators[including fasting plasma glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),and insulin resistance index(HOMA-IR)],and serum leptin were detected.Before and after intervention,the ovarian area of patients in both groups was measured by ultrasound.Results:①After intervention,the total clinical effective rate was 83.34%in the treatment group and 50.00%in the control group.The efficacy of the treatment group was better than that of the control group(P<0.05).②After intervention,the scores of menstrual condition,hirsutism,and acne,and SAS scores in both groups were significantly decreased compared with those before intervention(P<0.05,P<0.01),and the scores of menstrual condition and hirsutism,and SAS score in the treatment group were significantly lower than those in the control group(P<0.05).③After intervention,the levels of LH,T and AMH,and the LH/FSH ratio in both groups were decreased compared with those before intervention(P<0.05,P<0.01).However,there were no statistically significant differences in the levels of sex hormones between the two groups(P>0.05).④After intervention,the levels of FINS and HOMA-IR in both groups were significantly decreased compared with those before intervention(P<0.01).However,there were no statistically significant differences in the levels of glucose metabolism indicators between the two groups(P>0.05).⑤After intervention,the levels of TG,TC,and LDL-C in the treatment group were significantly decreased(P<0.05,P<0.01),the HDL-C level was increased(P<0.05),the levels of TC and LDL-C in the control group were also significantly decreased(P<0.05),and the HDL-C level of the treatment group was higher than that of the control group(P<0.01).⑥After intervention,the serum leptin levels of both groups were significantly decreased compared with those before intervention(P<0.01),and the serum leptin level of the treatment group was significantly lower than that of the control group(P<0.01).⑦Before and after intervention,there were no statistically significant differences in the ovarian area between and within the two groups(P>0.05).Conclusion:Tonifying kidney,reducing phlegm and removing blood stasis method combined with physical exercise can effectively improve the related symptoms and signs in overweight/obese patients with PCOS,reduce the body mass,correct the glucose and lipid metabolism disorders,alleviate the leptin resistance,and enhance the clinical efficacy.
polycystic ovarian syndromeoverweight/obesekidney-deficiency and phlegm-dampness typetonifying kidney,reducing phlegm and removing blood stasisphysical exercise