熊胆及其潜在替代资源研究概况
Review on bear bile and its potential alternative resources
张学延 1王天明 1吴家胜 1马越鸣1
作者信息
- 1. 上海中医药大学中药学院 上海201203
- 折叠
摘要
对比分析天然熊胆与熊胆的人工制品以及其他动物胆汁在化学成分、药理作用、临床应用等方面的异同.研究发现,人工合成熊胆在结合型胆汁酸牛磺熊去氧胆酸(TUDCA)、牛磺鹅去氧胆酸(TCDCA)的含量以及利胆、镇静、抗菌等药理作用方面在一定程度上已经达到天然熊胆的水平,可为寻找天然熊胆的替代资源提供参考.
Abstract
This article analyzed and compared the similarities and differences on chemical components,pharmacological effects and clinical application between natural bear bile and its artificial products or other animal bile.Research found that the contents of conjugated bile acids including tauroursodesoxycholic acid (TUDCA) and taurochenodeoxycholic acid(TCDCA) in artificially synthesized bear bile and its cholagogic,sedative and antibacterial effects were approximate to those of natural bear bile to some extent,which provided reference for searching alternative resources of natural bear bile.
关键词
熊胆/胆汁酸/化学成分/药理作用/临床应用/替代Key words
bear bile/bile acid/chemical components/pharmacological effects/clinical application/alternative resource引用本文复制引用
基金项目
国家“十二五”重大新药创制专项(ZX093013606-007)
出版年
2017
国家科技期刊平台
NSTL
维普
万方数据