Research progress on active components and pharmacological mechanisms of Astragali Radix in immunoregulation
The incidence of immune-related diseases is rising annually.Current primary therapeutic approaches,including immunosuppressants,glucocorticoids,and biologics,present challenges such as overtreatment,undertreatment,and significant adverse toxic effects.Huangqi(Astragali Radix)and its active components show significant immunomodulatory properties and possess pharmacological effects including bidirectional immune regulation,anti-inflammatory action,antioxidative stress response,and antitumor activity,which make it effective in treating immune-related diseases such as cancer,myasthenia gravis,inflammatory bowel disease,atopic dermatitis,and psoriasis.Huangqi can prevent and treat immune diseases through multiple pathways and targets.This article reviews the mechanisms by which Huangqi and its key active compounds(Astragaloside Ⅲ,Astragaloside Ⅳ,Cycloastragenol,and various flavonoids)regulate immune responses,thereby providing a foundation for further clinical research.
Huangqi(Astragali Radix)immunoregulationpharmacological effectactive componenttraditional Chinese herbal medicine research
NETL
NSTL
万方数据
