Role of NLRP3 inflammasome in osteo-sarcopenia and advances in intervention with traditional Chinese medicine monomers
Osteo-sarcopenia(OS)is a metabolic disease characterized by the simultaneous decline in muscle mass,function,and bone density and strength.The NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome plays a crucial role in the pathogenesis of OS.Persistent activation of the NLRP3 inflammasome can lead to pathological changes in the structure and function of the musculoskeletal system through various mechanisms,ultimately resulting in muscle bone co-reduction.By reviewing the role of the NLRP3 inflammasome in OS and the research progress of interventions with traditional Chinese medicine monomers,this paper aims to elucidate the pathogenesis of OS and provide a reference for the prevention and treatment of OS with traditional Chinese medicine.
osteo-sarcopeniasarcopeniaosteoporosisinflammationtraditional Chinese herbal medicine research
NETL
NSTL
万方数据
