NLRP3炎症小体在肌少-骨质疏松症中的作用及中药单体干预进展
Role of NLRP3 inflammasome in osteo-sarcopenia and advances in intervention with traditional Chinese medicine monomers
刘晏东 1张彦军 2毛家伟 2李中锋 2彭冉东 2陈博 2郭铁峰2
作者信息
- 1. 甘肃中医药大学研究生院(甘肃 兰州 730000)
- 2. 甘肃省中医院脊柱骨二科(甘肃 兰州 730050)
- 折叠
摘要
肌少-骨质疏松症(OS)是一种以肌肉的质量、功能以及骨骼密度、强度同步衰减为特征的代谢性疾病.NOD样受体家族核苷酸结合寡聚化结构域样受体3(NLRP3)炎症小体在OS的发病过程中扮演着重要的角色,NLRP3炎症小体的持续活跃可通过多种机制导致肌、骨系统的结构和功能发生病理改变,最终发生肌骨共减.通过综述NLRP3炎症小体在OS中的作用及中药单体对其干预的研究进展,揭示OS的发病机制,为中医药防治OS提供参考.
Abstract
Osteo-sarcopenia(OS)is a metabolic disease characterized by the simultaneous decline in muscle mass,function,and bone density and strength.The NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome plays a crucial role in the pathogenesis of OS.Persistent activation of the NLRP3 inflammasome can lead to pathological changes in the structure and function of the musculoskeletal system through various mechanisms,ultimately resulting in muscle bone co-reduction.By reviewing the role of the NLRP3 inflammasome in OS and the research progress of interventions with traditional Chinese medicine monomers,this paper aims to elucidate the pathogenesis of OS and provide a reference for the prevention and treatment of OS with traditional Chinese medicine.
关键词
肌少-骨质疏松症/肌肉减少症/骨质疏松症/炎症/中药研究Key words
osteo-sarcopenia/sarcopenia/osteoporosis/inflammation/traditional Chinese herbal medicine research引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据