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Eosinophil extracellular traps in respiratory ailment:Pathogenic mechanisms and clinical translation

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Background:Eosinophilic extracellular traps(EETs)are reticular complexes comprising deoxyribonucleic-Acid(DNA)fibers and granule proteins.Aims:EETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under degraded.EETs created by eosinophils appear to enable vital immune responses against extra-cellular pathogens,nevertheless,trap overproduction is evident in pathology.Materials & Methods:As considerably research is performed,new data affirmed that EETs can alter the outcome of respiratory ailment.Results:We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic,unresolved inflammation.Discussion:Whether EETs can be used as a prospective brand-new target for the diagnosis,treatment and prognosis of respiratory ailments is a scientific theme worth studying.Conclusion:We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic,unresolved inflammation.

cytolysisdegranulationeosinophil extracellular trapseosinophilsrespiratory ailments

Shun-Yu Wu、Bo-Yu Cai、Tian-Yu Wang、Zhi-Wen Cao、Hu Peng、Huan-Hai Liu

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Department of Otolaryngology,The Second Affiliated Hospital of the Naval Military Medical University(Shanghai Changzheng Hospital),Shanghai,China

Department of Otolaryngological,Shanghai Changzheng HospitalNational Science Foundation of ChinaNational Science Foundation of ChinaNational Science Foundation of China

0907815410388167090581870702

2024

10.1002/wjo2.138

世界耳鼻咽喉头颈外科杂志(英文)

世界耳鼻咽喉头颈外科杂志(英文)

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年,卷(期)：2024.10(3)