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脑胶质瘤免疫治疗与电场治疗的前沿进展

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脑胶质瘤是最常见的原发性颅内恶性肿瘤。由于脑胶质瘤的遗传学变异较强,患者个体差异大,并且进展过程中不易产生新突变和新抗原,因此靶向治疗的研究进程较其他肿瘤遇到了更多阻碍。免疫治疗和电场治疗是癌症治疗的新型理念,阶段性的突破极大地推动了脑胶质瘤研究领域的发展。本文对近年来脑胶质瘤治疗的新发现和新进展进行概述,以期为未来临床治疗脑胶质瘤提供参考。
Research progress in immunotherapy and tumor-treating fields for gliomas
Glioma is the most common primary intracranial malignant tumor.Due to the strong genetic variation and significant individual differences among patients,as well as the difficulty in generating new mutations and antigens during the progression of glioblastoma,the research progress of targeted therapy has encountered more obstacles compared to other tumors.Immunotherapy and tumor-treating fields(TTF)are new concepts in cancer treatment,and their phased breakthroughs have greatly inspired the field of glioma research.This article provides an overview of the new discoveries and advances in the treatment of gliomas in recent years,to provide reference for future clinical treatment of gliomas.

GliomaImmunotherapyTumor-treating fieldsClinical trialsReview

刘博涵、彭大钊、陈彦坤、胡慧敏

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100070 北京市神经外科研究所 首都医科大学附属北京天坛医院分子神经病理室

神经胶质瘤 免疫治疗 电场治疗 临床试验 综述

2025

神经疾病与精神卫生
齐齐哈尔医学院

神经疾病与精神卫生

影响因子:0.579
ISSN:1009-6574
年,卷(期):2025.25(1)