槲皮素对肝细胞性肝癌的增效减毒效应研究进展
Research Progress of Quercetin's Effects on Hepatocellular Carcinoma by Improving Treatments and Reducting Toxicity
李兴强 1晁旭 2冯雪松1
作者信息
- 1. 陕西中医药大学基础医学院 咸阳 712046
- 2. 陕西中医药大学基础医学院 咸阳 712046;陕西中医药大学第二附属医院 咸阳 712046
- 折叠
摘要
阿霉素、5-氟尿嘧啶和顺铂为临床上常用于治疗肝细胞性肝癌(Hepatocellular carcinoma,HCC)的化疗药物,化疗的同时易产生明显的毒副反应和多药耐药,影响治疗效果.因此,开发新型有效药物降低化疗引起的副作用势在必行.槲皮素是一种在安全剂量范围内天然无毒的黄酮醇类化合物,在过去的几十年里,槲皮素的多种抗肿瘤作用及其机制已被逐步挖掘,如促凋亡、抗增殖、抗炎和抗氧化作用等;槲皮素不仅能够增强化疗效果,还能够降低化疗中的不良反应.本文总结了槲皮素对HCC化疗药物增效减毒效应的研究概况,并展望了槲皮素作为治疗HCC的辅助药物应用于临床的发展前景.
Abstract
Doxorubicin,5-fluorouracil and cisplatin are commonly used in the treatment of hepatocellular carcinoma.These drugs shows obvious toxic side effects and patients always get multidrug resistance while using these drugs during chemotherapy.These effects hinder the progress and treatments of chemotherapy.Therefore,it has become imperative to develop new and effective drugs to prevent the side effects caused by chemotherapy.Quercetin is a naturally non-toxic flavonol within a safe dose range.In the past few decades,anti-tumor mechanisms of quercetin have been studied,such as pro-apoptotic,antiproliferative,anti-inflammatory and antioxidant effects.Several reports in recent years have found that quercetin plays an important role in adverse effects of anti-chemotherapy drugs and enhancing the efficacy of drugs.This article summarizes the research overview of the synergistic and antitoxicity effect of quercetin on the above-mentioned chemotherapy drugs for hepatocellular carcinoma.This review indicates the clinical potential of quercetin as an adjuvant drug for the treatment of hepatocellular carcinoma.
关键词
槲皮素/肝细胞性肝癌/化疗药物/增效减毒Key words
Quercetin/Hepatocellular carcinoma/Chemotherapy drugs/Synergistic and attenuated引用本文复制引用
基金项目
陕西省中医体质与疾病防治重点实验室开放基金(KF202311)
陕西中医药大学国家基金培育项目(2023GP16)
陕西中医药大学研究生质量提升工程专项(2023)(CXSJ202302)
出版年
2024
国家科技期刊平台
NSTL
万方数据