Research Progress of Quercetin's Effects on Hepatocellular Carcinoma by Improving Treatments and Reducting Toxicity
Doxorubicin,5-fluorouracil and cisplatin are commonly used in the treatment of hepatocellular carcinoma.These drugs shows obvious toxic side effects and patients always get multidrug resistance while using these drugs during chemotherapy.These effects hinder the progress and treatments of chemotherapy.Therefore,it has become imperative to develop new and effective drugs to prevent the side effects caused by chemotherapy.Quercetin is a naturally non-toxic flavonol within a safe dose range.In the past few decades,anti-tumor mechanisms of quercetin have been studied,such as pro-apoptotic,antiproliferative,anti-inflammatory and antioxidant effects.Several reports in recent years have found that quercetin plays an important role in adverse effects of anti-chemotherapy drugs and enhancing the efficacy of drugs.This article summarizes the research overview of the synergistic and antitoxicity effect of quercetin on the above-mentioned chemotherapy drugs for hepatocellular carcinoma.This review indicates the clinical potential of quercetin as an adjuvant drug for the treatment of hepatocellular carcinoma.
QuercetinHepatocellular carcinomaChemotherapy drugsSynergistic and attenuated
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