Information Combination Rule of TCM Four Diagnosis of Polycystic Ovary Syndrome Based on Principal Component Analysis and Cluster Analysis
Objective To explore the combination rule of the four diagnostic information of traditional Chinese medicine(TCM)of polycystic ovary syndrome(PCOS)for future classification and diagnosis.Methods The information of patients was retrospectively collected from Shuguang Hospitals Affiliated with Shanghai University of TCM and the Department of Gynecology,Shanghai Hospital of TCM from January 1,2020,to December 1,2022.Principal component analysis and cluster analysis were used to observe the combination rule of four diagnosis information.Result The KMO=0.534 and Bartlett=5035.306(P<0.001)were suitable for principal component analysis.The loading factor was obtained by rotating the component matrix pair with the maximum variance method,and the factor coefficient screened out the corresponding four diagnostic information of 19 principal components.According to the analysis of the cluster results based on the theory of TCM,the most common disease location elements were kidney,liver and spleen.It was determined that qi deficiency,qi stagnation,fire heat,yin deficiency,yang deficiency,phlegm dampness and blood stasis were the main pathogenic syndrome elements.Patients with PCOS could be classified mainly into following pattern types:Liver hyperactivity with spleen deficiency pattern;Deficiency of the spleen and kidney pattern concurrent Intertwined phlegm and blood stasis pattern;Spleen deficiency with damp heat pattern;Blood stasis of kidney deficiency pattern;Blood stasis due to qi stagnation pattern.Conclusion The four diagnostic information of PCOS patients have specific combination rules,which can provide an objective basis for the standardization and standardization of syndrome classification.
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