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运脾化痰通窍方提取工艺优化

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  • NETL
  • NSTL
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目的 实现运脾化痰通窍方提取工艺优选，并建立组方指纹图谱。方法 应用总量统计矩法，对提取液指纹图谱进行宏观表征和相似度分析，以黄芩苷、汉黄芩苷、迷迭香酸、甘草苷、甘草酸、出膏率为关键质量属性，以提取时间、加水倍量、提取次数为关键工艺参数，采用AHP-独立性权重法进行综合评分，优选出最佳提取工艺，并进行验证。结果 建立总量统计矩相似度评价方法，不同提取方法指纹图谱总量统计矩相似度均值为0。8807，工艺评价模型函数方差分析结果显示，P<0。0001、R2=0。9904，该模型具有统计学意义。优选得到最佳提取工艺为全方饮片加10倍量水，提取1。5 h，提取2次。结论 优化的工艺稳定可靠，建立了符合该方提取液指纹图谱特点的总量统计矩分析方法，为该方后续工艺研究全过程质量控制奠定物质基础。
Optimization of Extraction Process for Yunpi Huatan Tongqiao Decoction
Objective Establish the fingerprint of the group and optimize the extraction process of the Yunpi Huatan Tongqiao decoction.Methods The macroscopic characterization and similarity analysis of the extract fingerprint were carried out by applying the total statistical moment method.With baicalin,wogonin,rosmarinic acid,liquiritin,glycyrrhizic acid and paste yield as key quality attributes,and extraction time,water addition and extraction times as key process parameters,the optimal extraction process was selected by AHP-independent weight method,and the process was verified.Results Establishing a total statistical moment similarity evaluation method,and the average statistical moment similarity of the total amount of fingerprints of different extraction methods was 0.8807.The ANOVA results of the process evaluation model function are displayed that P<0.0001,R2=0.9904,indicating that the model was statistically significant.The best extraction process was determined as follows:adding 10-fold volume of water in the whole prescription,extracting for 1.5 h and extracting twice.Conclusion The total statistical moment analysis method that conforms to the fingerprint characteristics of the fingerprint of the extract was established,which was stable and reliable,which provided a reference basis for the quality control of the whole process of the subsequent process research.

Yunpi Huatan Tongqiao decoctionExtraction processBox-Behnken response surface methodFingerprintNalytic hierarchy process-independence weighting methodQuality control

余金凤、艾璟、栾宁、闫明、王振中、肖伟、于桂芳

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南京中医药大学康缘中药学院 南京 210023

江苏康缘药业股份有限公司 连云港 222001

中药制药过程控制与智能制造技术全国重点实验室 连云港 222001

南京中医药大学药学院 南京 210023

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运脾化痰通窍方 提取工艺 Box-Behnken设计-响应面法 指纹图谱 AHP-独立性权重法 质量控制

国家中医药局中央财政转移支付地方项目(2022)

2024

10.11842/wst.20240114002

世界科学技术-中医药现代化
中科院科技政策与管理科学研究所，中国高技术产业发展促进会

世界科学技术-中医药现代化

CSTPCD北大核心
影响因子：1.175
ISSN：1674-3849
年,卷(期)：2024.26(3)
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