首页|中医脾虚本质科学内涵研究之探讨

中医脾虚本质科学内涵研究之探讨

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脾虚是中医理论体系的重要组成部分,其在不同的历史时期经历了起源、规范、成熟、完善、发展的过程。中医脾的生理功能涉及"脾主运化、升清、统血";从脾本脏功能将"脾主运化"分解为"脾主运"和"脾主化"两部分进行研究,更有利于阐释脾主运化科学内涵。脾主运化是脾主升清的基础,脾主升清又是脾主运化的深化,脾主统血则是脾主升清的转归,三者存在递进的逻辑层次关系。随着蛋白质组学、代谢组学和肠道菌群研究的兴起,为脾虚的研究提供了技术支撑;另外,基于中医脾与内质网功能之间的关联性,从内质网应激角度探讨脾虚本质物质基础,为脾虚研究提供了新的方向。
Discussion on the Scientific Connotation of Spleen Deficiency in Traditional Chinese Medicine
Spleen deficiency is an important part of the theoretical system of Traditional Chinese Medicine,which has experienced the process of origin,standardization,maturity,perfection and development in different historical periods.The physiological function of the spleen in Traditional Chinese Medicine involves"the spleen governs transportation and transformation,promotes blood circulation";The study of"spleen governing transportation and transformation"divided into"spleen governing transportation"and"spleen governing transformation"from the function of spleen,which is more conducive to explaining the scientific connotation of spleen governing transportation and transformation.Spleen governing transport and transformation is the basis of spleen governing clearing,and spleen governing clearing is the purpose of spleen governing transport and transformation.Spleen governing blood circulation is the outcome of spleen governing clearing,and there is a progressive logical hierarchy relationship between them.With the rise of proteomics,metabonomics and intestinal flora research,it provides technical support for the study of spleen deficiency syndrome;In addition,based on the correlation between spleen of Traditional Chinese Medicine and the functions of endoplasmic reticulum,the material basis of essence of spleen deficiency is discussed from the perspective of endoplasmic reticulum stress,which provides a new direction for the study of spleen deficiency.

Spleen deficiencySpleen dominates transportationEndoplasmic reticulumMetabonomicsProteomicsIntestinal flora

吕林、王凤云、马祥雪、张北华、唐旭东

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中国中医科学院西苑医院脾胃病研究所 北京 100091

脾虚 脾主运化 内质网 代谢组学 蛋白质组学 肠道菌群

国家中医药局传承创新团队项目国家自然科学基金面上项目中国中医科学院创新工程培养项目

ZYYCXTD-C-20201081873297CI2021A01003

2024

世界科学技术-中医药现代化
中科院科技政策与管理科学研究所,中国高技术产业发展促进会

世界科学技术-中医药现代化

CSTPCD北大核心
影响因子:1.175
ISSN:1674-3849
年,卷(期):2024.26(3)
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