基于肠道菌群的脾虚证研究述评
A Review of Studies on Spleen Deficiency Syndrome Based on Intestinal Microflora
张坤漓 1吕咪 1胡佳艳 1余文熙 2乔希筠 1王昱茜 2王凤云1
作者信息
- 1. 中国中医科学院西苑医院 北京 100091
- 2. 北京中医药大学研究生院 北京 100029
- 折叠
摘要
人的胃肠道是机体最大的储菌库,定居着一个十分复杂和活跃的微生物群落,正常情况下,肠道菌群与宿主之间相互作用,保持着动态平衡.脾虚证是中医临床的常见经典证型,大量研究表明,脾虚证与肠道微生物关系密切,肠道菌群的平衡是脾主运化功能正常发挥的基础,肠道菌群失调则会出现一系列脾虚的表现.此外,肠道菌群是健脾中药多糖成分代谢、发挥疗效的重要介质,而健脾中药也可以通过调节肠道菌群的结构和数量,发挥治疗作用.本文总结了肠道菌群与脾虚证在生理、病理以及健脾中药药效发挥上的关联,立足于肠道菌群研究脾虚证,旨在为揭示中医脾虚证的内涵提供一些思考与建议.
Abstract
The human gastrointestinal tract is the largest reservoir of bacteria in the body,inhabiting a very complex and active microbial community.Under normal circumstances,the interaction between the intestinal flora and the host maintains a dynamic balance.Spleen deficiency syndrome is a common classic syndrome type in TCM clinical practice.A large number of studies have shown that spleen deficiency syndrome is closely related to intestinal microorganisms,and the balance of intestinal flora is the basis for the normal functioning of the spleen's main transportation and transformation functions.Intestinal flora imbalance can lead to a series of manifestations of spleen deficiency.In addition,intestinal flora is an important medium for the metabolism of polysaccharide components and the effectiveness of traditional Chinese medicine for invigorating the spleen,and traditional Chinese medicine for invigorating the spleen can also play a therapeutic role by regulating the structure and quantity of intestinal flora.This article summarizes the relationship between intestinal flora and spleen deficiency syndrome in physiology,pathology,and the efficacy of traditional Chinese medicine for invigorating the spleen.Based on intestinal flora,the study of spleen deficiency syndrome aims to provide some thoughts and suggestions for revealing the connotation of spleen deficiency syndrome in traditional Chinese medicine.
关键词
脾虚证/肠道菌群/多糖/中药Key words
Spleen deficiency syndrome/Intestinal microflora/Polysaccharide/Traditional Chinese medicine引用本文复制引用
基金项目
国家自然科学基金面上项目(82174363)
国家自然科学基金面上项目(82374434)
中国中医科学院科技创新工程重点项目(CI2021A01001)
出版年
2024
国家科技期刊平台
NSTL
万方数据