从"脾为之卫"理论探讨肠道黏膜免疫与溃疡性结肠炎的中医机制
To Explore the Mechanism of Intestinal Mucosal Immunity and Ulcerative Colitis in Chinese Medicine from Perspective of"Spleen as the Defense"
马祥雪 1温永天 1尹晓岚 1张北华 1唐旭东1
作者信息
- 1. 中国中医科学院西苑医院脾胃病研究所 北京 100091
- 折叠
摘要
溃疡性结肠炎(Ulcerative colitis,UC)的发病机制尚不明确,肠道黏膜免疫功能紊乱是目前研究UC发病机制的热点.脾虚是UC发病的基础,"脾为之卫"功能失常是UC肠道黏膜免疫稳态失衡的关键原因.本文以"脾为之卫"为切入点,探讨UC肠黏膜免疫功能紊乱的机制,为从脾论治UC夯实理论基础,且为从恢复肠黏膜免疫稳态角度治疗UC提供理论依据.
Abstract
The pathogenesis of ulcerative colitis(UC)is still unclear,and the pathogenesis based on intestinal mucosal immune imbalance is now widely recognized."Spleen as the defense"refers to the function of the spleen to protect the body and defend against pathogenic factors,which is highly consistent with modern mucosal immunology theory.The abnormal function of"Spleen as the defense"is the key reason for the immune imbalance of UC intestinal mucosa.In this paper,"spleen as the defense"as the starting point,to explore the mechanism of UC intestinal mucosal immune dysfunction,to consolidate the theoretical basis for the treatment of UC based on spleen,and to provide a theoretical basis for the treatment of UC from the perspective of restoring intestinal mucosal immune homeostasis.
关键词
脾为之卫/脾虚/肠道黏膜免疫/溃疡性结肠炎Key words
"Spleen as the defense"/Spleen deficiency/Intestinal mucosal immunity/Ulcerative colitis引用本文复制引用
基金项目
国家自然科学基金青年基金(81804089)
中华中医药学会青年人才托举工程项目(2021-QNRC1-01)
国家中医药局传承创新团队项目(ZYYCXTD-C-202010)
出版年
2024
NETL
NSTL
万方数据