首页|从"脾为之卫"理论探讨肠道黏膜免疫与溃疡性结肠炎的中医机制

从"脾为之卫"理论探讨肠道黏膜免疫与溃疡性结肠炎的中医机制

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溃疡性结肠炎(Ulcerative colitis,UC)的发病机制尚不明确,肠道黏膜免疫功能紊乱是目前研究UC发病机制的热点。脾虚是UC发病的基础,"脾为之卫"功能失常是UC肠道黏膜免疫稳态失衡的关键原因。本文以"脾为之卫"为切入点,探讨UC肠黏膜免疫功能紊乱的机制,为从脾论治UC夯实理论基础,且为从恢复肠黏膜免疫稳态角度治疗UC提供理论依据。
To Explore the Mechanism of Intestinal Mucosal Immunity and Ulcerative Colitis in Chinese Medicine from Perspective of"Spleen as the Defense"
The pathogenesis of ulcerative colitis(UC)is still unclear,and the pathogenesis based on intestinal mucosal immune imbalance is now widely recognized."Spleen as the defense"refers to the function of the spleen to protect the body and defend against pathogenic factors,which is highly consistent with modern mucosal immunology theory.The abnormal function of"Spleen as the defense"is the key reason for the immune imbalance of UC intestinal mucosa.In this paper,"spleen as the defense"as the starting point,to explore the mechanism of UC intestinal mucosal immune dysfunction,to consolidate the theoretical basis for the treatment of UC based on spleen,and to provide a theoretical basis for the treatment of UC from the perspective of restoring intestinal mucosal immune homeostasis.

"Spleen as the defense"Spleen deficiencyIntestinal mucosal immunityUlcerative colitis

马祥雪、温永天、尹晓岚、张北华、唐旭东

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中国中医科学院西苑医院脾胃病研究所 北京 100091

脾为之卫 脾虚 肠道黏膜免疫 溃疡性结肠炎

国家自然科学基金青年基金中华中医药学会青年人才托举工程项目国家中医药局传承创新团队项目

818040892021-QNRC1-01ZYYCXTD-C-202010

2024

世界科学技术-中医药现代化
中科院科技政策与管理科学研究所,中国高技术产业发展促进会

世界科学技术-中医药现代化

CSTPCD北大核心
影响因子:1.175
ISSN:1674-3849
年,卷(期):2024.26(3)
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