首页|基于脾-线粒体相关性探讨ICC功能障碍

基于脾-线粒体相关性探讨ICC功能障碍

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功能性胃肠病(Functional gastrointestinal disorders，FGIDs)症状重叠常常存在病情错综复杂、临床中诊疗困难、易加重患者的心理、经济负担及造成相应的医疗资源的消耗等现状。研究发现，功能性消化不良(Functional dyspepsia，FD)和胃食管反流病(Gastroesophageal reflux disease，GERD)可能存在潜在的病理生理学联系，目前主要认为与食管下括约肌松弛及胃排空延迟所致胃肠道动力障碍有关。脾为后天之本，气血生化之源，布散精微于周身，蕴含机体所需能量及物质。线粒体有"动力工厂"之称，通过三羧酸循环及氧化磷酸化生成ATP为机体生命活动提供能量的同时还可以生成血红素。脾与线粒体的功能体现了相同生命活动的两种不同诠释方式。相关研究认为，辨证为脾虚时线粒体能量代谢障碍所致的Cajal间质细胞(Interstitial cells of Cajal，ICC)功能障碍与胃肠动力障碍关系密切。故本文基于"脾与线粒体"相关性，探讨ICC功能障碍与FD-GERD症状重叠的关系，提出脾虚与线粒体能量代谢障碍引发ICC功能障碍是造成FD-GERD症状重叠的重要因素。除此之外，从通降理论入手，可以为诊治FD-GERD症状重叠提供较高的临床实用价值。
To Explore ICC Dysfunction Based on Spleen-Mitochondria Correlation
The overlapping symptoms of functional gastrointestinal disorders(FGIDs)are complicated,which makes the diagnosis and treatment of FGIDs more difficult,at the same time aggravates the patients'psychological and economic burden and results in the consumption of medical resources.Functional dyspepsia(FD)and gastroesophageal reflux disease(GERD)may have a potential Pathophysiology relationship,which is mainly related to gastrointestinal motility disorders caused by lower esophageal sphincter relaxation and delayed gastric emptying.The spleen is the foundation of nurture,the source of Qi and blood biochemistry,disperses the fine in the whole body,contains the energy and the material which the organism needs.Mitochondria are known as"Power factories",producing heme as well as ATP from tricarboxylic acid cycle and oxidative phosphorylation to fuel life.The functions of spleen and mitochondria embody the same life activity in two different ways.It has been found that the dysfunction of interstitial cells of cajal(ICC)caused by energy metabolism disorder of mitochondria is closely related to gastrointestinal motility disorder.Therefore,based on the"Correlation between spleen and mitochondria",this paper discusses the relationship between ICC dysfunction and overlapping FD and GERD.It is suggested that the dysfunction of ICC caused by spleen deficiency and mitochondrial energy metabolism disorder is the important pathogenesis of overlapping FD and GERD.In addition,starting from the theory of Tong Jiang,it can provide higher clinical practical value for the diagnosis and treatment of overlapping FD and GERD.

Correlation of spleen and mitochondriaInterstitial cells of CajalSymptoms overlapFunctional dyspepsiaGastroesophageal reflux diseaseTheory of Tong Jiang

卫裕晨、王一茗、张泰、亢晶、张北华、唐旭东

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北京中医药大学研究生院 北京 100029

中国中医科学院西苑医院脾胃病研究所 北京 100091

脾与线粒体 Cajal间质细胞 症状重叠 功能性消化不良 胃食管反流病 通降理论

国家中医药局传承与创新团队项目中医药治疗难治性胃肠病的传承与创新团队项目

ZYYCXTD-C-202010

2024

10.11842/wst.20230509007

世界科学技术-中医药现代化
中科院科技政策与管理科学研究所，中国高技术产业发展促进会

世界科学技术-中医药现代化

CSTPCD北大核心
影响因子：1.175
ISSN：1674-3849
年,卷(期)：2024.26(3)
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