目的 研究单味中药及复方治疗盆腔炎性疾病后遗症的作用机制.方法 对Pubmed、Web of Science、中国知网和万方等数据库进行检索,寻找建库至2023年3月以来关于中药治疗SPID及作用机制的相关文献,并对文献进行归纳整理.结果 共纳入文献428篇,从纳入文献中筛选出从调节细胞因子和炎症介质分泌水平、促进炎症细胞凋亡、抑制脂质过氧化、抑制组织纤维化、改善血液循环、调节代谢途径和细胞信号转导、调节免疫能力等方面报道单味中药及复方治疗盆腔炎性疾病的作用机制.结论 为中药治疗盆腔炎性疾病后遗症作用机制进行深入研究,并对其新药研发提供参考.
Research Progress on the Mechanism of Traditional Chinese Medicine in Treating Sequelae of Pelvic Inflammatory Diseases
Objective To study the mechanism of single Chinese medicine and compound in the treatment for sequelae of pelvic inflammatory disease.Methods We searched Pubmed,Web of Science,CNKI,Wanfang and other databases,to find out relevant literature on the treatment of SPID and their mechanism of herbal medicine since the etablishment of the database to March 2023,and summarized the literatures.Results A total of 428 literatures were included,from the included literature,we screened reports on the mechanism of of single Chinese medicine and compound in the treatment of pelvic inflammatory disease,including regulating the secretion level of cytokines and inflammatory mediators,promoting the apoptosis of inflammatory cells,inhibiting lipid peroxidation,inhibiting tissue fiber,improving blood circulation,regulating metabolic pathways and cell signal transduction,and regulating immunity etc.Conclusion To conduct in-depth research on the mechanism of action of traditional Chinese medicine in the treatment of sequelae of pelvic inflammatory disease and to provide reference for the development of new drugs of SPID.
Sequelae of pelvic inflammatory disease(SPID)Traditional Chinese medicine(TCM)Mechanism of action
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